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Creatine Monohydrate

HCID 80116
NotesReactions
Basic informationNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
Substructure searchFind similar structures

Basic information

CAS
6020-87-7
Standard SMILES
CN(CC(=O)O)C(=N)N.O
InChIKey
MEJYXFHCRXAUIL-UHFFFAOYSA-N
Molecular formula
C4H11N3O3
Average molar mass
149.15 g/mol
Monoisotopic mass
149.08004122

Names & identifiers

Preferred name
Creatine Monohydrate
IUPAC
2-[carbamimidoyl(methyl)amino]acetic acid;hydrate
English name
Creatine monohydrate
Molecular formula
C4H11N3O3
Molecular weight
149.15

Names & synonyms

Creatine monohydrate6020-87-7Creatine, monohydrateCreapureGlycine, N-(aminoiminomethyl)-N-methyl-, monohydrateUNII-9603LN7R2Q9603LN7R2QN-(Aminoiminomethyl)-N-methylglycine monohydrateDTXSID10208954CREATINE MONOHYDRATE [WHO-DD]Glycine, N-(aminoiminomethyl)-N-methyl-, hydrate (1:1)Creatine Supplement
Show more names
Creatine MonoCreatine Ethyl EsterN-GUANYL-N-METHYLGLYCINECreatine monohydrate powderCREATINE MONOHYDRATE 200 MESHN-AMIDINOSARCOSINEN-AMIDINOSARCOSINE MONOHYDRATECreatine Monohydrate, 99% 100GRCREATINE MONOHYDRATE EXTRA PURE
RefChem:128421DTXCID60131445N-(aminoiminomethyl)-N-methyl-Glycine, monohydrate611-954-82-(1-Methylguanidino)acetic acid hydrateCreatine hydrateMFCD00071582Creatine (monohydrate)

Database identifiers

CAS
6020-87-7
PubChem CID
80116
DTXSID
DTXSID10208954
ChEMBL
CHEMBL5275950
UNII
9603LN7R2Q
EC Number
611-954-8

Properties

Computed structural properties

Topological polar surface area
91.4 Ų
Hydrogen bond donors
4
Hydrogen bond acceptors
4
Rotatable bonds
3
Heavy atoms
10
Formal charge
0
Complexity
134

Physicochemical properties

Melting point
292 °C · 292 °C (dec.)(lit.)
Density
0.55 · 0.55-0.64 g/cm3
RTECS
7706000 · MB7706000
storage temp.
2 · 2-8°C
solubility
slightly soluble in water, insoluble in ethanol and ether.
form
Crystalline Powder
color
White to yellow
Odor
Odorless
PH
6.9 · 6.9 (10g/l, H2O, 20℃)
Water Solubility
13 g/L · 13 g/L (20 ºC)
Merck
14 · 14,2568
BRN
907175 · 907175
Stability
Hygroscopic
Cosmetics Ingredients Functions
SKIN CONDITIONING
InChI
InChI=1S/C4H9N3O2.H2O/c1-7(4(5)6)2-3(8)9;/h2H2,1H3,(H3,5,6)(H,8,9);1H2
InChIKey
MEJYXFHCRXAUIL-UHFFFAOYSA-N
SMILES
N(C)(C(N)=N)CC(=O)O.O

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 69.4% (102 of 147) of all reports.

Warning

H315 (30.6%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (30.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (29.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 147 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 102 of 147 reports by companies.;There are 6 notifications provided by 45 of 147 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 3 items

Chemical: Glycine, N-(aminoiminomethyl)-N-methyl-, monohydrate

Regulation (EC) No 178/2002 (amended)

Creatine: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesSkin Irrit. 2 (30.6%);Eye Irrit. 2 (30.6%);STOT SE 3 (29.9%)

Regulatory information

Chemistry & industry

Applications · 3 items

DescriptionCreatine Monohydrate is the monohydrate form of creatine similar or identical to endogenous creatine produced in the liver, kidneys, and pancreas. Pure creatine is a white, tasteless,odorless powder, that is a naturally occurring metabolite found in muscle tissue.Creatine monohydrate is an amino acid produced in the human body that plays a role in replenishing the energy supply to muscle cells.Creatine is usually produced to a purity of 99.5 percent or higher.Until recently, the primary use for creatine was as a laboratory reagent, demand for which was relatively limited.In the early 1990's, however, weight trainersand other athletes began using creatine in the belief that it stimulates muscle growth and reduces muscle fatigue.

UsesCreatine is a natural compound made from the amino acids l-arginine, glycine, and methionine.Creatine monohydrate is a creatine with one molecule of water connected to it. Our bodies can produce creatine, however they also can take in and store creatine found in diverse meals like meat, eggs, and fish.Creatine monohydrate supplementation is promoted as an ergogenic aid, which refers to a product purported to enhance energy production,utilization, control, and efficiency (Mujika and Padilla,1997).Creatine is purported to increase power, strength, and muscle mass and to decrease performance time (Demant et al.,1999).Involved with rapid ATP production primarily in skeletal muscle tissue via the action of creatine kinase(s).

UsesCreatine monohydrate is involved in rapid ATP production primarily in skeletal muscle tissue via the action of creatine kinase(s). It may be used as a supplement to study its uptake mechanism and metabolism of action. It is used in the treatment of neuromuscular diseases.

Preparation methods · 1 item

PreparationCreatine monohydrate can be synthesized in the laboratory (and commercially), starting from cyanamide and sarcosine (N-methylglycine).Creatine is a nitrogenous organic acid that occurs naturally in vertebrates and helps to supply energy to all cells in the body, primarily muscle by playing a key role in muscle energy metabolism. It is produced in the liver, pancreas, and kidneys and can also be derived from food and dietary supplements. Creatine provides the energy needed for muscle contraction and substantially improves performance in high-intensity exercise because it improves anaerobic capacity and protein synthesis. Therapeutically, it has been used to treat some types of muscular dystrophy, ocular atrophy, and some types of sclerosis. Creatine (a dietary supplement) is demanded by many athletes and is neither regulated by the Food and Drug Administration (FDA) nor prohibited by the International Olympic Committee (IOC).

Related reactions

19 records
New reaction record
HRID 657439 reaction equation
HRID 657439As reactantuspto-grants-2011_12
HRID 657440 reaction equation
HRID 657440As reactantuspto-grants-2011_12
HRID 657441 reaction equation
HRID 657441As reactantuspto-grants-2011_12
HRID 863207 reaction equation
HRID 863207As productuspto-grants-1998_02
HRID 863208 reaction equation
HRID 863208As productuspto-grants-1998_02
HRID 1419203 reaction equation
HRID 1419203As reactantuspto-grants-1999_03
HRID 1419204 reaction equation
HRID 1419204As reactantuspto-grants-1999_03
HRID 1516963 reaction equation
HRID 1516963As productuspto-grants-2012_07
Page 1 of 3

Compound notes

Loading…

On this pageBasic informationNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
LogP
-1.877 · -1.877 (est)
CAS DataBase Reference
6020 · 6020-87-7(CAS DataBase Reference)
EWG's Food Scores
1 · 1
FDA UNII
9603 LN7R2Q · 9603LN7R2Q
NCI Drug Dictionary
creatine monohydrate
NIST Chemistry Reference
Creatine hydrate(6020-87-7)
UNSPSC Code
41116107 · 41116107
NACRES
26 · NA.26
CAS Number Unlabeled
6020 · 6020-87-7
Symbol(GHS)
7 · GHS07
Signal word
Warning
Hazard statements
315 · H315-H319-H335
Precautionary statements
261 · P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
PPE
95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes
Xi,Xn
Risk Statements
36 · 36/37/38-20/21/22
Safety Statements
26 · 26-36
WGK Germany
1 · 1
Autoignition Temperature
800 °C · >800°C
TSCA
Yes
HS Code
29252000 · 29252000
Storage Class
11 · 11 - Combustible Solids
Regulatory Information · 3 items

Chemical: Glycine, N-(aminoiminomethyl)-N-methyl-, monohydrate

Regulation (EC) No 178/2002 (amended)

Creatine: Does not have an individual approval but may be used under an appropriate group standard

Safety data

PPE
dust mask type N95 (US), Eyeshields, Gloves
wgk
1
tsca
Yes
hs_code
29252000
risk_code
36/37/38-20/21/22
Signal word
Warning
Symbol(GHS)
GHS07
hazard_code
Xi,Xn
safety_code
26-36
Storage Class
11 - Combustible Solids
Hazard statements
H315-H319-H335
Autoignition Temperature
>800°C
Precautionary statements
P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Upstream & downstream products

Upstream raw materials

Sarcosine(AMIDINOTHIO)ACETIC ACID

Downstream products

Creatine phosphate disodium salt

Suppliers100 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
河南萨克斯生物科技有限公司13803717460 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖北常奥药业有限公司027-87058617 13419515565
河南福雷斯特新材料科技有限公司18639096640 · [email protected]
科瑞迪化学400-821-5857 021-64326257 · [email protected]
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
Syntechem Co.,Ltd[email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
阿法埃莎(中国)化学有限公司400-6106006 · [email protected]
安耐吉化学&3A(安徽泽升科技股份有限公司)400-0056266 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
上海柯维化学技术有限公司021-64609169 18901607656 · [email protected]
上海泰坦科技股份有限公司400-6009262 15618770481 · [email protected]
张家港市思普生化有限公司512-0512-58992291,58992287 18606280718 · [email protected]
武汉丰泰威远科技有限公司027-87465837 19945049750 · [email protected]
孝感深远化工有限公司15527621225; 15527621225 · [email protected]
Beckmann-Kenko GmbH+49 4241 9308 88 · [email protected]
玛雅试剂+86 (573) 82222445 (0)18006601000 452520369 · [email protected]
四川库利南科技有限公司400-1166-196 18981987031 · [email protected]
天津希恩思生化科技有限公司400 638 7771 · [email protected]
湖南汇百侍生物科技有限公司0731-85526065 13308475853 · [email protected]
斯百全化学(上海)有限公司021-021-021-67601398-809-809-809 15221380277 · [email protected]
上海源叶生物科技有限公司13636370518 · [email protected]
艾科试剂4008-755-333 18080918076 · [email protected]
青岛保税区鲁联国际贸易有限公司0532-83893697 18561902820 · [email protected]
上海思域化工科技有限公司86-21-34053660 · [email protected]
赛默飞世尔科技(中国)有限公司800-810-5118 · [email protected]
北京伊诺凯科技有限公司400-810-7969 010-59572699 · [email protected]
江苏艾康生物医药研发有限公司025-66113011 13913916777 · [email protected]
TCI AMERICA800-4238616 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
上海贤鼎生物科技有限公司4009209199 · [email protected]
深圳振强药物研发有限公司0755-66853366 13670046396 · [email protected]
南京杜莱生物技术有限公司025-84699383-8003;025-846993838003-8003 18013301590 · [email protected]
上海陶素生化科技有限公司021-33632979 · [email protected]
深圳市石金谷科技有限公司(0086)755-61930359 (0086)18038192047 · [email protected]
上海倍卓生物科技有限公司021-61119791,13386096464 · [email protected]
上海湄水化工科技有限公司021-60549325 18616193163
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
上海将来实业股份有限公司021-61552785 · [email protected]
HBCChem, Inc.+1-510-219-6317 · [email protected]
日照力德士化工有限公司010-51268198 · [email protected]
美岚实业(上海)有限公司021-58958189 · [email protected]
上海爱蝶实业有限公司021-58957966 18930537195 · [email protected]
四川省维克奇生物科技有限公司028-81700200 18116577057 · [email protected]
成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
湖北瑞今化学有限公司027 83642615 13995607107 · [email protected]