Diethylamine

Nitrogen Compounds -> Amines, Aliphatic

Corrosives

log Kow = 0.58

0.580

0.58

0.57

0.708 at 68 °F (USCG, 1999) - Less dense than water; will float

0.7056 g/cu cm at 20 °C

Critical density: 0.246 g/cc

Saturated liquid density: 44.090 lb/cu ft; liquid heat capacity: 0.601 Btu/lb-F; liquid thermal conductivity: 0.850 Btu-inch/hr-sq ft-F; saturated vapor pressure: 3.933 lb/sq in; saturated vapor density: 0.05059 lb/cu ft (all at 70 °F)

Relative density (water = 1): 0.7

0.71

greater than or equal to 100 mg/mL at 63 °F (NTP, 1992)

In water, infinitely soluble /1X10+6 mg/L/ at 25 °C

Miscible with water, alcohol

Soluble in ether and carbon tetrachloride

Miscible with most organic solvents

For more Solubility (Complete) data for DIETHYLAMINE (6 total), please visit the HSDB record page.

Danger

H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Danger

H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Chemical: Ethanamine, N-ethyl-

Ethanamine, N-ethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanamine, N-ethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 02-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/13453

Ethanamine, N-ethyl-: HSNO Approval: HSR001127 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Special Hazards of Combustion Products: Vapors are irritating

· Flammable/combustible material.

Flammable. Gives off irritating or toxic fumes (or gases) in a fire. Vapour/air mixtures are explosive.

Irritation and burning of eyes, skin, and respiratory system. High concentration of vapor can cause asphyxiation. (USCG, 1999)

· May cause toxic effects if inhaled or ingested.

Diethylamine can cause necrosis to the skin. Rabbits exposed to 100 ppm, 7 hours/day, 5 days/week for 6 weeks have bronchopneumonia; [ACGIH] If left on clothing, can cause reddening of skin; [CHRIS] Corrosive to skin; [Quick CPC] Causes liver damage in high-dose animal studies; [HSDB] A corrosive substance that can cause pulmonary edema; [ICSC]

1154 132

1154 132

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Use powder, alcohol-resistant foam, water in large amounts, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position.

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer immediately for medical attention.

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

(General first aid procedures)

· Wear positive pressure self-contained breathing apparatus (SCBA).

184.0 [ppm]

2.0 [ppm]

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

Use water spray to keep fire exposed containers cool. Use water spray, dry chemical, or "alcohol resistant" foam. Aqueous solutions will burn unless diluted thoroughly with spray.

For more Fire Fighting Procedures (Complete) data for DIETHYLAMINE (6 total), please visit the HSDB record page.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids.

Separate from oxidizing materials, acids, & sources of halogens. Store in cool, dry, well-ventilated, noncombustible location.

Keep well closed.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

1. Remove all ignition sources; 2. Ventilate area of spill or leak; 3. For small quantities, absorb on paper towels. Evaporate in safe place (such as fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn paper in suitable location away from combustible materials.

Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. Neutralize with sodium bisulfate (NaHSO4).

Environmental considerations-water spill: Add sodium bisulfate (NaHSO4). If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.

Environmental considerations-air spill: Apply water spray or mist to knock down vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material; Contaminated packaging: Dispose of as unused product.

Diethylamine is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration.

/Absorb small spills with paper and/ burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device.

Infant C57BL and C3HF1 male mice were given diethylamine hydrochloride (DEA-HCl) and sodium nitrite (50 ug/g intragastrically either singly or in combination). Animals were sacrificed periodically up to 110 wk. Histological exam of the liver revealed that mice given DEA-HCl and sodium nitrite had significantly more liver tumors compared to mice given only sodium nitrate or DEA-HCl. This suggests the formation of a potent carcinogen in vivo by the interaction of DEA-HCl and sodium nitrite. /DEA-HCl/

Nitrite ... is used as a food additive in meats and smoked fish. Some fish, vegetables, and fruit juices contain secondary amines. The acidic environment of the stomach facilitates a chemical reaction between nitrite and secondary amines, leading to the formation of carcinogenic nitrosamines. /Secondary amines/

LC50; Species: Pimephales promelas (Fathead minnow) age 30 days; Conditions: flow through, 24.7 °C, pH 7.71, dissolved oxygen 7.1 mg/L, hardness 48.5 mg/L CaCO3, alkalinity 49.5 mg/L CaCO3; Concentration: 855 mg/L for 96 hr /98% purity/

LC50; Species: /Oncorhynchus mykiss/ (rainbow trout); Concentration: 25-182 mg/L for 96 hr /conditions of bioassay not specified/

EC50; Species: Anabaena subcylindrica (Blue-green algae) axenic, 1-3x 10+7 cells/mL; Conditions: freshwater, static, 25 °C, pH 7.2; Concentration: 7.8x10-8 ug/cell for < or = 3 hr; Effect: decreased nitrogen fixation

EC50; Species: Anabaena subcylindrica (Blue-green algae) axenic, 1-3x 10+7 cells/mL; Conditions: freshwater, static, 25 °C, pH 7.2; Concentration: 7.7x10-8 ug/cell for < or = 3 hr; Effect: decreased photosynthesis, oxygen production

For more Ecotoxicity Values (Complete) data for DIETHYLAMINE (10 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 27(SRC), determined from a structure estimation method(2), indicates that diethylamine is expected to have very high mobility in soil(SRC). The pKa of diethylamine is 11.09(3), indicating that this compound will exist entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of diethylamine from moist soil surfaces is not expected to be an important fate process(SRC) given its cationic state(SRC). Diethylamine is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 237 mm Hg at 25 °C(5). Between 69 and 89% of the Theoretical BOD was achieved for diethylamine using an activated sludge inoculum digested for 4 weeks(6), suggesting biodegradation may be an important fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 27(SRC), determined from a structure estimation method(2), indicates that diethylamine is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 11.09(3) indicates diethylamine will exist entirely in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). Diethylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.58(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Diethylamine, present at 10 ppm, reached 38% of its Theoretical BOD in 12 days using freshwater/sediment inoculum(7). The biodegradation half-life of diethylamine in stream water was 0.9 days at an initial concentration of 10 mg/L(8).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethylamine, which has a vapor pressure of 237 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 hours(SRC), calculated from its rate constant of 8.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Diethylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

Fresh fruit and vegetables, preserved and processed foods purchased from retail outlets were analyzed for the content of diethylamine. It was not detected in fresh cabbage, red cabbage, cauliflower, kale, white or red beet, carrots, large or red radish, celery, rhubarb, corn, green salad, preserved kale, pickled cabbage, cheese, coffee, cocoa, tea or white wine. Other food products contained diethylamine as follows(1):[Table#1504]

Diethylamine has been identified as a volatile component of boiled beef(1).

The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

IDENTIFICATION AND USE: Diethylamine (DEN) is a colorless liquid with fishy, ammonia-like odor. It is used in petroleum industry, in flotation agents, dyes, pharmaceuticals. It also used as a selective solvent for the removal of impurities from oils, fats, and waxes, and as a corrosion inhibitor in iron, steel, and metal industries. HUMAN EXPOSURE AND TOXICITY: Adult volunteers were exposed to 25 ppm (75 mg/cu m) diethylamine in a climate chamber for 15 min in order to study the acute nasal reactions to an exposure equivalent to the present threshold limit value-short-term exposure limit. Exposure to a concentration increasing from 0 to 12 ppm took place for 60 min, equal to an average concentration of 10 ppm (30 mg/cu m). A moderate to strong olfactory response and distinct nasal and eye irritation were observed. Edema of the epithelium of the cornea, generally without pain, has been produced by diethylamine vapors, causing colored halos to be seen around lights. The edema of the corneal epithelium, which is principally responsible for the disturbance of vision, clears spontaneously by the next day, but after exceptionally intense exposures the edema and blurring have taken several days to clear and have been accompanied by photophobia and discomfort from roughness of the corneal surface. ANIMAL STUDIES: Rabbits were exposed to DEN vapors at 50 and 100 ppm, 7 hours/day, 5 days/week for 6 weeks. All rabbits survived the exposures and had normal body weights without demonstrating any outward signs of response to the chemical. At 100 ppm, lungs contained cellular infiltration and bronchopneumonia; livers had parenchymatous degeneration with evidence of cell regeneration; and kidneys showed nephritis. The same changes, but to a lesser degree, were produced at 50 ppm. A suggestion of very slight cardiac muscle degeneration was seen in rabbits inhaling 50 ppm but was not evident at 100 ppm. Male and female rats were exposed at 0,25 or 250 ppm diethylamine (DEA) vapor, 6.5 hr per day, 5 days per week, for 24 weeks in order to assess cardiac and other organ system toxicity. During the first 2 weeks of exposure, the rats exposed at 250 ppm DEA did not gain weight. After 2 weeks, however, the rate of weight gain of these rats was greater than that of controls. Nevertheless, mean body weights for both sexes of rats exposed at 250 ppm DEA remained depressed compared to controls throughout the study. Sneezing, tearing, and reddened noses were seen in rats exposed at 250 ppm DEA. Histopathologic examinations revealed lesions of the nasal mucosa of rats exposed at 250 ppm DEA. These lesions of the respiratory epithelium consisted of squamous metaplasia, suppurative rhinitis, and lymphoid hyperplasia. There were no pronounced treatment-related effects on organ weights, hematology, or clinical chemistry indices except for blood urea nitrogen which was evaluated in rats of both sexes exposed at 250 ppm DEA for 24 weeks. In contrast to the high-dose animals, no treatment-related effects were observed in rats intermittently exposed at 25 ppm DEA for up to 24 weeks. No evidence of cardiotoxicity was seen in rats exposed to either DEA concentration for up to 24 weeks. Diethylamine was evaluated for mutagenicity in the Salmonella/microsome preincubation assay. Diethylamine was tested at doses of 0, 10, 33, 100, 333, 1000, and 3333 ug/plate in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) with or without metabolic activation. Diethylamine was negative in these tests. Diethylamine was not mutagenic in either of two independent bacterial mutagenicity assays, each conducted with and without exogenous metabolic activation enzymes. Bacterial strains tested included Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA/pKM101. In addition to the negative results in the two bacterial assays, no significant increases in the frequencies of micronucleated erythrocytes were seen in peripheral blood of male or female mice from the 3-month study. NTP conducted 2 year inhalation studies in rats and mice. There was no evidence of carcinogenic activity of diethylamine in male or female rats exposed to 31, 62.5, or 125 ppm. There was no evidence of carcinogenic activity of diethylamine in male or female mice exposed to 16, 31, or 62.5 ppm. Exposure to diethylamine resulted in increased incidences of nonneoplastic lesions of the nose in male and female rats and mice, of the cornea in male rats, and of the pleura and lung in female rats.

Sore throat. Cough. Shortness of breath. Burning sensation behind the breastbone. Symptoms may be delayed.

Redness. Pain. Blisters. Serious skin burns.

Redness. Pain. Burns.

Burning sensation in the throat and chest. Abdominal pain. Diarrhoea. Vomiting. Shock or collapse.

irritation eyes, skin, respiratory system; in animals; myocardial degeneration

EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPA; ICSS Dashboard Application; Available from, as of July 7, 2016: http://actor.epa.gov/dashboard/]

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Short-Term Toxicity Studies", "Long-Term Carcinogenicity Studies", and "Genetic Toxicology Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of July 28, 2016: http://ntp.niehs.nih.gov/testing/status/agents/ts-10992-k.html]

Diethylamine was identified, not quantified, in volatiles from a cattle feed yard(1), the exhaust from a gasoline engine(2), furniture coatings(3) and textile floor coverings(4). The emission rate of diethylamine from the interior materials to the air in new cars was 9.6, 8.1 and 5.7 ug/hour after aging 0, 20 and 40 days, respectively(5). Diethylamine was detected in effluent from waste water treatment plants collected from Jiaula River Basin, China at 1.41, 0.22-10.53 and 0.86-1.76 ug/L in samples collected Nov 2010, Jan 2011 and Mar 2011, respectively(6).

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Ethanamine, N-ethyl- is included on this list. Effective date: 6/1/87; Sunset date: 6/1/97.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Diethylamine is produced, as an intermediate or a final product, by process units covered under this subpart.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Diethylamine is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.

Used in the manufacture of rubber, petroleum products, resins, dyes, and pharmaceuticals; [Merck Index] Used as a corrosion inhibitor, rubber accelerator, and polymerization inhibitor; Also used in electroplating and as an organic intermediate; A metabolite of the drug disulfiram used in the treatment of alcohol abuse; [ACGIH]

Electroplating [Category: Plate]

Rubber chemicals, textile specialties, selective solvent, dyes, flotation agents, resins, pesticides, polymerization inhibitors, pharmaceuticals, petroleum chemicals, electroplating, corrosion inhibitors.

In the rubber and petroleum industry. In flotation agents; resins, dyes, buffer formulations, and pharmaceuticals.

CHEMICAL INT IN SYNTH OF RUBBER-PROCESSING CHEMICALS, DIETHYLAMINO ETHANOL FOR MEDICINALS, & 3-DIETHYLAMINO PROPYLAMINE, 2-DIETHYLAMINO ETHYL METHACRYLATE & N,N-DIETHYL- M-TOLUAMIDE (INSECT REPELLENT)

Used for the manufacture of diethyldithiocarbamate and thiurans (rubber processing accelerators)

2023: 10,000,000 - <50,000,000 lb

(1972) 5.04X10+9 GRAMS

(1975) 5.64X10+9 GRAMS

(1981) 15,932X10+3 lb

(1984) 8.40X10+9 g

For more U.S. Production (Complete) data for DIETHYLAMINE (8 total), please visit the HSDB record page.

CATALYTIC REACTION OF AMMONIA AND ETHYL ALCOHOL AT HIGH TEMPERATURE AND PRESSURE

Preparation from ethyl iodide and NH3 with sepn of mono-, di-, and triethylamines formed. ... Manufactured from ethanol and NH3, obtained along with mono- and triethylamines.

Ammonia, alcohol, and hydrogen are passed continuously over a catalyst in a gas-solid heterogenous reaction.

Ammonia, aldehyde or ketone, and hydrogen are passed continuously over a catalyst under careful monitoring.

For more Methods of Manufacturing (Complete) data for DIETHYLAMINE (6 total), please visit the HSDB record page.

98.5% minimum purity

Grade: Technical

Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing

Ethanamine, N-ethyl-: ACTIVE