Diethylamine → Acetoacetamide, N,N-diethyl-

Reaction equation

[C:1]([O:7]CC)(=O)[CH2:2][C:3]([CH3:5])=[O:4].[CH2:10]([NH:12][CH2:13][CH3:14])[CH3:11]>>[CH2:10]([N:12]([CH2:13][CH3:14])[C:1](=[O:7])[CH2:2][C:3](=[O:4])[CH3:5])[CH3:11]

Participants

Reactant 2

HCID 8021Diethylamine

HCID 8868Ethyl Acetoacetate

Product 1

HCID 16699Acetoacetamide, N,N-diethyl-Yield 65.7%

Procedure

40 g (0.31 mol) of ethyl acetoacetate and 24 g (0.33 mol) of diethylamine were stirred in a Parr apparatus at 150° C. for 10'. The crude mixture was distilled at 115°-120° C./9 mmHg, to give 32 g of the title compound.

Workup

distillationThe crude mixture was distilled at 115°-120° C./9 mmHg

Sources & evidence

ORD record: ord-51c44092234a4bbebe6940b7ac132c46
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05731322

Reaction notes

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