Hexafluoropropylene

Other Classes -> Halogenated Aliphatics, Unsaturated

Reactive agents - 1st degree

PFAS -> Other/unspecified

PFAS -> PFAS identified in REACH Regulation EC No. 1272/2008

PFAS -> Other/unspecified

PFAS -> Other/unspecified

PFAS -> Intentionally added food contact chemicals

1.583 AT -40 °C/4 °C

1.583 @ -40°C

-29.6 °C

-29.6 °C @760 [mm Hg]

-156.5 °C

-156.5 °C

4900.0 [mmHg]

4.9X10+3 mm Hg at 25 °C /from experimentally derived coefficients/

750 [mm Hg] @-30.6 °C

FCS -> FDA Cumulative Estimated Daily Intake (CEDI)

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Hexafluoropropylene is an odorless, colorless gas. It is noncombustible. It can asphyxiate by the displacement of air. Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket.

Liquid; Gas Vapor

An odorless, colorless, noncombustible gas that can act as a simple asphyxiant; [CAMEO]

Warning

H332: Harmful if inhaled [Warning Acute toxicity, inhalation]

P261, P271, P304+P340, P317, P319, P403+P233, P405, and P501 (click each P-code to see the statement)

Warning

H280 (89.5%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]

P203, P260, P261, P264, P270, P271, P273, P280, P304+P340, P308+P316, P317, P318, P319, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement)

Chemical: 1-Propene, 1,1,2,3,3,3-hexafluoro-

1-Propene, 1,1,2,3,3,3-hexafluoro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Propene, 1,1,2,3,3,3-hexafluoro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 03-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15192

Hexafluoropropene: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

· Some may burn but none ignite readily.

· Some may burn but none ignite readily.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

· Vapors may cause dizziness or asphyxiation without warning, especially when in closed or confined areas.

· Vapors may cause dizziness or asphyxiation without warning, especially when in closed or confined areas.

1858 126

1858 126

FLUOROALKANES; RESPONSE TO THE INTERAGENCY TESTING COMMITTEE; FED REGIST 46(210 BK 1) 53704 (1981). EVIDENCE SUPPORTING NEED FOR EVALUATING TOXICITY OF FLUOROALKANES IS DISCUSSED. THE COMPOUNDS (FLUOROALKANES) ARE USED PRIMARILY IN SYNTH OF POLYMERS & COPOLYMERS, RESISTANT TO HEAT & CORROSION. THEIR CHEM PROPERTIES, MFR WORKER EXPOSURE POTENTIAL, & ADEQUACY OF INFORMATION ON ONCOGENICITY, MUTAGENICITY, & OTHER TOXIC EFFECTS ARE COVERED.

Halogenated aliphatic compounds, such as HEXAFLUOROPROPYLENE, are moderately or very reactive. Halogenated organics generally become less reactive as more of their hydrogen atoms are replaced with halogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Above a minimum oxygen pressure, the reaction of oxygen difluoride and hexafluoropropene to yield the hexafluoropropylene oxide becomes explosive, Chem. Abs., 1987, 107, 175302. The reaction of hexafluoropropene with grignard reagent (subst. phenylmagnesium bromides) led to explosion, Fluorine Chem., 1981, 18, 25.

/GUIDE 126: GASES - COMPRESSED OR LIQUEFIED (INCLUDING REFRIGERANT GASES)/ Fire or Explosion: Some may burn, but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket.

/GUIDE 126: GASES - COMPRESSED OR LIQUEFIED (INCLUDING REFRIGERANT GASES)/ Health: Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating, corrosive and/or toxic gases.

/GUIDE 126: GASES - COMPRESSED OR LIQUEFIED (INCLUDING REFRIGERANT GASES)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. Ventilate closed spaces before entering.

/GUIDE 126: GASES - COMPRESSED OR LIQUEFIED (INCLUDING REFRIGERANT GASES)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing will only provide limited protection.

For more DOT Emergency Guidelines (Complete) data for 1,1,2,3,3,3-HEXAFLUORO-1-PROPENE (8 total), please visit the HSDB record page.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch or walk through spilled material.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch or walk through spilled material.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

General First Aid:

General First Aid:

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Immediate precautionary measure

Immediate precautionary measure

40 [ppm]

91 [ppm]

480 [ppm]

· Use extinguishing agent suitable for type of surrounding fire.

· Use extinguishing agent suitable for type of surrounding fire.

ERPG-1: 10 ppm - one hour exposure limit: 1 = mild transient health effects or objectionable odor [AIHA]

Emergency Response Planning Guidelines (ERPG): ERPG(1) 10 ppm (no more than mild, transient effects) for up to 1 hr exposure; ERPG(2) 50 ppm (without serious, adverse effects) for up to 1 hr exposure; ERPG(3) 500 ppm (not life threatening) up to 1 hr exposure.

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 470(SRC), determined from a structure estimation method(2), indicates that hexafluoropropene is expected to have moderate mobility in soil(SRC). Volatilization of hexafluoropropene is expected from moist soil surfaces(SRC) given an estimated Henry's Law constant of 5.34 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Hexafluoropropene is expected to rapidly volatilize from dry soil surfaces based on a vapor pressure of 4.9X10+3 mm Hg(SRC), determined from a fragment constant method(4). Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(5).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 470(SRC), determined from a structure estimation method(2), indicates that hexafluoropropene is expected to adsorb to suspended solids and sediment in water(SRC). Hexafluoropropene is expected to volatilize rapidly from water surfaces(3,SRC) based on an estimated Henry's Law constant of 5.34 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated half-lives for a model river and model lake are 4 and 116 hours, respectively(3,SRC). According to a classification scheme(5), an estimated BCF value of 24(3,SRC), from an estimated log Kow of 2.12(6,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hexafluoropropene, which has a vapor pressure of 4.9X10+3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase hexafluoropropene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone molecules(SRC); the half-lives for these reactions in air are estimated to be about 21(3,SRC) and 95(4,SRC) days, respectively.

Using a structure estimation method based on molecular connectivity indices(1), the Koc for hexafluoropropene can be estimated to be about 470(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that hexafluoropropene is expected to have moderate mobility in soil(SRC).

The ability of hexafluoropropene (HFP) to cause aberrations in Chinese hamster ovary (CHO) cells in vitro was evaluated in the presence and absence of rat liver S9 metabolic activation. Based on preliminary toxicity tests, nonactivated cultures were treated with 0, 0.01, 0.02, 0.10, 0.17, 0.29, 0.37, 0.43 or 0.59% HFP and activated cultures were treated with 0, 0.09, 0.17, 0.33, 0.46, 0.55, 0.67, 0.85, 1.40% HFP. Significant increases were observed in numbers of aberrations/cell, percent abnormal cells, and percent cells with >1 aberration relative to controls in nonactivated and activated cultures at the highest four dose levels (0.29% and 0.55% and above, respectively). Positive dose-related trends were observed for all three measurements in both nonactivated and activated cultures.

An estimated BCF value of 24 was calculated for hexafluoropropene(SRC), using an estimated log Kow of 2.12(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for hexafluoropropene is estimated as 5.34 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that hexafluoropropene will volatilize rapidly from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 4 hours(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 116 hours(2,SRC). Hexafluoropropene's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces is expected(SRC). Hexafluoropropene is expected to volatilize rapidly from dry soil surfaces based on a vapor pressure of 4.9X10+3 mm Hg at 25 °C(3).

MALE RATS EXPOSED TO AIR CONTAINING SUBLETHAL CONCN OF HEXAFLUOROPROPENE SHOWED INCR IN URINARY FLUORIDE AFTER EXPOSURE. INHALATION ALSO PRODUCED INCR IN URINARY EXCRETION OF POTASSIUM ION (K-+) & CREATININE, & A DIURESIS WHICH PERSISTED FOR 2 WK POST-EXPOSURE. HISTOLOGICALLY, FRANK NECROSIS OF PROXIMAL RENAL TUBULES WERE OBSERVED.

MALE FISCHER-344 RATS WERE SUBJECTED TO 4 HR INHALATION OF HEXAFLUOROPROPENE AT 380-1200 PPM. WITHIN 2 DAYS RATS EXHIBITED DOSE-RELATED PROXIMAL TUBULAR NECROSIS, DIURESIS, INCREASES IN URINARY FLUORIDE, URINARY LACTIC DEHYDROGENASE (LDH) ACTIVITY, SERUM CREATININE & BLOOD UREA NITROGEN. IT PRODUCED NECROSIS OF PARS RECTA & PARS CONVOLUTA PORTIONS OF PROXIMAL TUBULE. AT LOWEST CONCN DIURESIS WAS MOST SENSITIVE INDEX OF TOXICITY MANIFESTING 50% INCR IN WATER INTAKE & 25% DECR IN URINE OSMOLALITY. INCREASES IN URINARY LDH ACTIVITY CORRELATED WITH DEGREE OF PROXIMAL RENAL TUBULAR NECROSIS, WITH GREATER THAN 100-FOLD INCR AT HIGHEST CONCN. ALL CONCN PRODUCED NECROSIS WITHIN 24 HR POSTEXPOSURE, WITH TUBULAR CELL REGENERATION APPARENT WITHIN 4 DAYS.

The rate constant for the vapor-phase reaction of hexafluoropropene with photochemically-produced hydroxyl radicals has been estimated as 7.74X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 21 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). The rate constant for the vapor-phase reaction of hexafluoropropene with ozone has been measured as 7.7X10-20 cu cm/molecule-sec at 25 °C(2). This corresponds to an atmospheric half-life of about 95 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2,SRC). Hexafluoropropene is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(SRC).

About 90% is used as a monomer in closed systems to produce fluoropolymers, fluoroelastomers, and fluorolubricants; About 10% is used to produce replacement chlorofluorocarbons; [ACGIH]

MONOMER FOR FLUORINATED ETHYLENE-PROPYLENE COPOLYMERS

COMONOMER FOR VINYLIDENE FLUORIDE ELASTOMERS

CHEM INT FOR PERFLUOROALKYL POLYETHER FLUIDS

Production of copolymers and hexafluoropropylene oxide.

2023: 10,000,000 - <25,000,000 lb

(1977) AT LEAST 4.54X10+8 GRAMS

(1981) PROBABLY GREATER THAN 2.27X10+6 GRAMS

BY-PRODUCT IN THE PRODUCTION OF TETRAFLUOROETHYLENE BY REACTION OF HYDROGEN FLUORIDE WITH CHLOROFORM IN THE PRESENCE OF ANTIMONY TRIFLUORIDE CATALYST, FOLLOWED BY PYROLYSIS; PYROLYSIS OF POLYTETRAFLUOROETHYLENE; FLUORINATION OF 1,2,3-TRICHLOROPROPANE, THEN DEHALOGENATION

Produced by temperature controlled pyrolysis of chlorodifluoromethane. Also obtained from tetrafluoroethylene by heating at normal or reduced pressure in the presence of an inert gas or water vapor.

Industrial Gas Manufacturing

1-Propene, 1,1,2,3,3,3-hexafluoro-: ACTIVE

/DURING THERMAL DECOMPOSITION OF TETRAFLUOROETHYLENE/ WHEN AIR IS PRESENT & WITH TEMP OF...400 °C SMALL AMT OF PERFLUOROISOBUTYLENE...HEXAFLUOROPROPENE & OCTAFLUOROCYCLOBUTANE.../ARE PRODUCED/.