2-Chloro-3-methylpyridine

HCID 87603CAS 18368-76-8
Substructure searchFind similar structures

Basic information

Standard SMILES
Cc1cccnc1Cl
InChIKey
RKVUCIFREKHYTL-UHFFFAOYSA-N
Molecular formula
C6H6ClN
Average molar mass
127.57 g/mol
Monoisotopic mass
127.01887687

Names & identifiers

Preferred name
2-Chloro-3-methylpyridine
IUPAC
2-chloro-3-methylpyridine
English name
2-Chloro-3-methylpyridine
Molecular formula
C6H6ClN
Molecular weight
127.57

Names & synonyms

2-Chloro-3-methylpyridine18368-76-8EINECS 242-242-1DTXSID00171461RefChem:468727DTXCID2093952242-242-12-Chloro-3-picoline2-Chloro 3-methylpyridineMFCD00234177Pyridine, 2-chloro-3-methyl-2-chloro-3-methyl-pyridine
Show more names
2-Chlor-3-methylpyridin2-CHLORO-3-METHYLPYRRIDINE2-Chloro-3-Pilcoline2-CHLORO-3-METHYLP...2-Chloro-3-picoline,98%2-Choro-3-methypyridine2-Chloro-3-mehyl pyridine
2-chloro-methyl-pyridine2-Chloro-3-methylpyridine, 97%AB05179SY017766C1885EN300-560573-Picoline, 2-chloro-2-chloro-3-methyl pyridine

Database identifiers

CAS
18368-76-8
PubChem CID
87603
DTXSID
DTXSID00171461
ChEMBL
CHEMBL4648536
EC Number
242-242-1
Nikkaji
J100.608H

Properties

Computed structural properties

XLogP
2.2
Topological polar surface area
12.9 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
1
Rotatable bonds
0
Heavy atoms
8

Physicochemical properties

Melting point
193 °C · 193 °C
Boiling point
192 · 192-193 °C/751 mmHg (lit.)
Density
1.17 g/mL · 1.17 g/mL at 25 °C (lit.)
refractive index
20 · n20/D 1.533(lit.)
Flash point
175 °F · 175 °F
storage temp.
Inert atmosphere,Room Temperature

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H302 (12.8%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 47 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (12.8%)

Safety data

PPE
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
wgk
3
ridadr
2810
hs_code
29333990
risk_code
36/37/38-20/21/22
Signal word
Warning

Chemistry & industry

Applications · 2 items

Description2-Chloro-3-methylpyridine is an intermediate for many medicines and pesticides, such as fluazifop, nicosulfuron, and fluazifop. Moreover, with the gradual promotion of these new high-efficiency and low-toxic heterocyclic pesticides, 2-chloro-3-methylpyridine is increasing. The industrial method for preparing 2-chloro-3-methylpyridine is to obtain it by site-specific chlorination of 3-methylpyridine. First, 3-methylpyridine is epoxidized and then chlorinated. The main chlorinated 3-methylpyridine is a mixture of 2-chloro-3-methylpyridine and 2-chloro-5-methylpyridine, of which 2-chloro-3-methylpyridine accounts for 20% (mass).

Uses2-Chloro-3-methylpyridine is an active ingredient and a major constituent of imidaclopide, a systemic insecticide that acts as insect neurotoxin and belongs to a class of chemical called the neonicotinoids.

Upstream & downstream products

Suppliers50 total

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
河南多贝化工有限公司0370-6999054 17550096163 · [email protected]

Related reactions

15 records
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Linked notes

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