Piperazine → 1-(3-Methyl-2-pyridinyl)piperazine

HRID 845202

Reaction equation

Cl[C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>>[CH3:8][C:7]1[C:2]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 876032-Chloro-3-methylpyridine

Product 1

HCID 27600571-(3-Methyl-2-pyridinyl)piperazine

Procedure

Reaction of the 2-chloro-3-methylpyridine with piperazine in a sealed bomb further using the procedure of Example 1 above resulted in a 50% yield of the desired IIIc product.

Workup

customabove resulted in a 50% yield of the desired IIIc product

Sources & evidence

ORD record: ord-042c180789f5436bb766b0f1fe27b582
Source dataset: uspto-grants-1988_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04757073

Linked notes

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