Aminoacetaldehyde dimethyl acetal

HCID 89728
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Basic information

CAS
22483-09-6
Standard SMILES
COC(CN)OC
InChIKey
QKWWDTYDYOFRJL-UHFFFAOYSA-N
Molecular formula
C4H11NO2
Average molar mass
105.14 g/mol
Monoisotopic mass
105.07897859

Names & identifiers

Preferred name
Aminoacetaldehyde dimethyl acetal
IUPAC
2,2-dimethoxyethanamine
English name
Aminoacetaldehyde dimethyl acetal
Molecular formula
C4H11NO2
Molecular weight
105.14

Names & synonyms

22483-09-6Aminoacetaldehyde dimethyl acetal2,2-Dimethoxyethylamine2,2-DimethoxyethanamineEthanamine, 2,2-dimethoxy-Acetaldehyde, amino-, dimethyl acetalXF4JYB7VV5EINECS 245-026-5NSC 73701NSC-73701DTXSID7066803ETHYLAMINE, 2,2-DIMETHOXY-
Show more names
2,2-dimethoxy-ethanaminAMINOACETOLDEHYDE DIMETHYL ACETOL2,2-Dimethyethanamine2-AMINOACETALDEHYDE DIMETHYLACETALAminoacetaldehyde dimethyl acetal ,98%AMINOACETALDEHYDE DIMETHYL ACETAL (OR) 2,2- DIMETHOXYETHYLAMINE (ADMA)anjiahuanchun
RefChem:557526DTXCID1036709Acetaldehyde, amino-, dimethyl acetal (8CI)2,2-DIMETHOXYETHAN-1-AMINEGlycinal Dimethyl AcetalMFCD000081352,2-dimethoxy-ethylamine2-AMINOACETALDEHYDE DIMETHYL ACETAL

Database identifiers

CAS
22483-09-6
PubChem CID
89728
DTXSID
DTXSID7066803
UNII
XF4JYB7VV5
EC Number
245-026-5
Nikkaji
J26.136J

Properties

Computed structural properties

XLogP
-0.8
Topological polar surface area
44.5 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
3
Rotatable bonds
3
Heavy atoms
7

Experimental & physicochemical properties

SpringerMaterials PropertiesOptical coefficient
Density0.957 @25 °C
Boiling Point128 °C @760 [mm Hg]
Melting Point-45 °C
Vapor Pressure7.5 [mm Hg] @20 °C

Physicochemical properties

Melting point
-78 °C · -78°C
Boiling point
135 · 135-139 °C/95 mmHg (lit.)
Density
0.965 g/mL · 0.965 g/mL at 25 °C (lit.)
refractive index
20 · n20/D 1.417(lit.)
Flash point
128 °F · 128 °F
storage temp.
2 · Keep in dark place,Inert atmosphere,2-8°C

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 1.4% (1 of 69) of reports.

Danger

H226 (98.6%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 69 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 3 items

Chemical: Ethanamine, 2,2-dimethoxy-

Status: Active Update: 04-03-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/21032

Aminoacetaldehyde dimethyl acetal: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesFlam. Liq. 3 (98.6%)

Safety & protection

Protective Action Criteria (PAC) · 3 items

12 [mg/m3]

130 [mg/m3]

790 [mg/m3]

Safety data

PPE
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk
2
tsca
TSCA listed
ridadr
UN 1993 3/PG 3
hs_code
29225000
risk_code
10-34-36/37/38

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationEthanamine, 2,2-dimethoxy-: ACTIVE
Applications · 3 items

DescriptionAminoacetaldehyde dimethyl acetal, also known as 2,2-dimethoxy-ethylamine, is a critical intermediate in the synthesis of ivabradine hydrochloride, proline analogs, praziquantel, and other raw materials. The existing process for producing aminoacetal dimethyl acetate uses vinyl acetate as the starting material, and the target product is synthesized through bromination, Gabriel synthesis, and hydrazinolysis.

UsesAmino acetaldehyde dimethyl was used in preparation of chitosan- dendrimer hybrids having various functional groups such as carboxyl, ester and poly(ethylene glycol). It was used in an synthesis of a bicyclic proline analog from L-ascorbic acid and in 3-component reaction catalyzed by MgClO4 leading to α-aminophosphonates.

General DescriptionAminoacetaldehyde dimethyl acetal reacts with sulfone, followed by hydrolysis and reductive amination by adding desired piperazine derivative to yield piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine.

Upstream & downstream products

Suppliers100 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Related reactions

548 records
New reaction record

Compound notes

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