CAS 22990-77-8 Piperidine-2-methylamine (HCID 90865)

Overview

2-Piperidinemethanamine is a member of piperidines.

Names & identifiers

Preferred name: Piperidine-2-methylamine
IUPAC: piperidin-2-ylmethanamine
English name: 2-PIPERIDYLMETHYLAMINE
Molecular formula: C6H14N2
Molecular weight: 114.19

Names & synonyms

2-PiperidinemethanaminePiperidine-2-methylamineEINECS 245-371-1EC 245-371-1RefChem:863579245-371-122990-77-82-PIPERIDYLMETHYLAMINE2-(Aminomethyl)piperidinepiperidin-2-ylmethanamine2-Aminomethylpiperidine2-(AMINOMETHYL)-1-PIPERIDINE

Show more names

2AMPPR2-(Aminomethyl)2-PIPERIDYLMETHYLAMIPiperidine-2-methanamine2-AMINOMETHYL PIPERIDINEFlecainide EP Impurity B

1-(piperidin-2-yl)methanamineMFCD00129011Piperidine, 2-(aminomethyl)-2-Aminomethyl-1-piperidine(RS)-(Piperidin-2-yl)methanamine(piperidin-2-yl)methanamineFlecainide Acetate Imp. B (EP); (RS)-(Piperidin-2-yl)methanamine; Flecainide Acetate Impurity B; Flecainide Impurity B2-piperidylmethanamine

Database identifiers

CAS: 22990-77-8
PubChem CID: 90865
DTXSID: DTXSID80945687
ChEBI: CHEBI:229435
UNII: 9Y4RLA45BH
EC Number: 245-371-1
Nikkaji: J43.049H

Properties

Computed structural properties

XLogP: -0.2
Topological polar surface area: 38.1 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 2
Rotatable bonds: 1
Heavy atoms: 8
Formal charge: 0
Complexity: 63.5

Physicochemical properties

Boiling point: 63 · 63-66°C/12mm
Density: 0.9406 g/mL · 0.9406 g/mL at 25 °C
refractive index: 1.485 · 1.4850
Flash point: 63 · 63-66°C/12mm
storage temp.: -20 °C · -20°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: 10.32 · 10.32±0.29(Predicted)
color: Clear Colorless
BRN: 102994 · 102994
InChI: InChI=1S/C6H14N2/c7-5-6-3-1-2-4-8-6/h6,8H,1-5,7H2
InChIKey: RHPBLLCTOLJFPH-UHFFFAOYSA-N
SMILES: N1CCCCC1CN
CAS DataBase Reference: 22990 · 22990-77-8(CAS DataBase Reference)
FDA UNII: 9 Y4RLA45BH · 9Y4RLA45BH
UNSPSC Code: 41116107 · 41116107
NACRES: 24 · NA.24
Symbol(GHS): 5 · GHS05
Signal word: Danger
Hazard statements: 314 · H314
Precautionary statements: 280 · P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes: C
Risk Statements: 34 · 34
Safety Statements: 26 · 26-36/37/39-45
RIDADR: 2735 · 2735
WGK Germany: 2 · 2
HazardClass: 8 · 8
PackingGroup: III
HS Code: 29333990 · 29333990
Storage Class: 8 A · 8A - Combustible corrosive hazardous materials
Hazard Classifications: 1 B · Skin Corr. 1B
REACH Registrations: Active
Limited Quantities: 1 L · 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H302 (65.5%): Harmful if swallowed [Warning Acute toxicity, oral]

P260, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 168 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory InformationStatus: Active Update: 06-07-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/20343

Hazard Classes and CategoriesAcute Tox. 4 (65.5%)

Safety data

PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk: 2
ridadr: 2735
hs_code: 29333990
risk_code: 34
Signal word: Danger
Symbol(GHS): GHS05
hazard_code: C
safety_code: 26-36/37/39-45
hazard_class: 8
Storage Class: 8A - Combustible corrosive hazardous materials
packing_group: III
Hazard statements: H314
Limited Quantities: 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
REACH Registrations: Active
Hazard Classifications: Skin Corr. 1B
Precautionary statements: P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405

Chemistry & industry

Applications

UsesReactant for reversible aminal formationReactant for synthesis of:Annulated N-heterocyclic carbene ligandsM3 Muscarinic receptor antagonistsSelective 5-ht5A receptor antagonistsTernary platinum(II) complexes

Uses2-Piperidinemethanamine is used in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. It also is used in the synthesis of potent antibacterial.