1,1'-Carbonyldiimidazole → hexahydroimidazo[1,5-a]pyridin-3(2H)-one

HRID 1775508

Reaction equation

HRID 1775508 reaction equation
C1N=CN([C:6](N2C=NC=C2)=[O:7])C=1.[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[CH2:19][NH2:20]>C(Cl)Cl>[CH2:19]1[CH:14]2[CH2:15][CH2:16][CH2:17][CH2:18][N:13]2[C:6](=[O:7])[NH:20]1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 90865Piperidine-2-methylamine

Product 1

HCID 47002315hexahydroimidazo[1,5-a]pyridin-3(2H)-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of CDI (830 mg, 5.1 mmol) and piperidin-2-ylmethanamine (520 mg, 4.6 mmol) in DCM (20 mL) was stirred at room temperature overnight. After the solvent was removed, the residue was directly used for the next step without further purification.

Workup

  1. customAfter the solvent was removed
  2. customthe residue was directly used for the next step without further purification

Sources & evidence

ORD record
ord-619ee6518b044e9c8f2128490bba4c10
Source dataset
uspto-grants-2016_02
Patent number
US09260452B2

Linked notes

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