p-(1-Piperazinyl)phenol (HCID 92467)

Names & identifiers

Preferred name: p-(1-Piperazinyl)phenol
IUPAC: 4-piperazin-1-ylphenol
English name: 1-(4-Hydroxyphenyl)piperazine
Molecular formula: C10H14N2O
Molecular weight: 178.23

Names & synonyms

1-(4-Hydroxyphenyl)piperazine56621-48-8p-(1-Piperazinyl)phenolEINECS 260-289-6DTXSID80205197RefChem:857911DTXCID80127688260-289-64-(piperazin-1-yl)phenol4-(1-Piperazinyl)phenol4-piperazin-1-ylphenolN-(4-hydroxyphenyl)piperazine

Show more names

RARECHEM AH CK 0119SALOR-INT L497754-1EALABOTEST-BB LT002331984-PIPERAZIN-1-YL-PHENOLKetoconazole Impurity 324-(1-Piperazino)phenol,98%

4-PiperazinophenolMFCD00066156Phenol, 4-(1-piperazinyl)-1-(4-Hydroxyphenyl)-piperazine4-piperazinylphenolEN300-172304-(1-piperazino)phenol4-Piperazinyl phenol

Database identifiers

CAS: 56621-48-8
PubChem CID: 92467
DTXSID: DTXSID80205197
UNII: A2SA24RA7S
EC Number: 260-289-6
Nikkaji: J267.059C

Properties

Computed structural properties

XLogP: 0.8
Topological polar surface area: 35.5 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 3
Rotatable bonds: 1
Heavy atoms: 13
Formal charge: 0
Complexity: 149

Physicochemical properties

Melting point: 220 °C · 220 °C
Boiling point: 371.3 · 371.3±27.0 °C(Predicted)
Density: 1.141 · 1.141±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Powder
pka: 12.18 · 12.18±0.30(Predicted)
color: Brownish
BRN: 150964 · 150964
InChI: InChI=1S/C10H14N2O/c13-10-3-1-9(2-4-10)12-7-5-11-6-8-12/h1-4,11,13H,5-8H2
InChIKey: GPEOAEVZTOQXLG-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(N2CCNCC2)C=C1
LogP: 0.374 · 0.374
CAS DataBase Reference: 56621 · 56621-48-8(CAS DataBase Reference)
FDA UNII: 2 SA24RA7S · A2SA24RA7S
UNSPSC Code: 12352100 · 12352100
Symbol(GHS): 7 · GHS07,GHS05,GHS06
Signal word: Warning
Hazard statements: 315 · H315-H319-H335-H301-H314-H318
Precautionary statements: 261 · P261-P305+P351+P338-P260h-P301+P310a-P303+P361+P353-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38
Safety Statements: 26 · 26-36
RIDADR: 3263 · UN3263
WGK Germany: 3 · 3
F: 10 · 10-34
Hazard Note: Irritant
HazardClass: 8 · 8
PackingGroup: III
HS Code: 29335990 · 29335990
Storage Class: 8 A · 8A - Combustible corrosive hazardous materials
Hazard Classifications: 1 Skin · Eye Dam. 1Skin Corr. 1B
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 4.2% (2 of 48) of reports.

Danger

H314 (10.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory InformationStatus: Active Update: 15-12-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/21519

Hazard Classes and CategoriesSkin Corr. 1B (10.4%)

Safety data

F: 10-34
PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 3
ridadr: UN3263
hs_code: 29335990
risk_code: 36/37/38
Signal word: Warning
Symbol(GHS): GHS07,GHS05,GHS06
hazard_code: Xi
hazard_note: Irritant
safety_code: 26-36
hazard_class: 8
Storage Class: 8A - Combustible corrosive hazardous materials
packing_group: III
Hazard statements: H315-H319-H335-H301-H314-H318
REACH Registrations: Active
Hazard Classifications: Eye Dam. 1Skin Corr. 1B
Precautionary statements: P261-P305+P351+P338-P260h-P301+P310a-P303+P361+P353-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313