Basic information
- CAS
5422-34-4- Standard SMILES
CC(O)C(=O)NCCO- InChIKey
RZCHTMXTKQHYDT-UHFFFAOYSA-N- Molecular formula
- C5H11NO3
- Average molar mass
- 133.15 g/mol
- Monoisotopic mass
- 133.07389321
Overview
N-Lactoyl ethanolamine is a N-acylethanolamine.
Names & identifiers
- Preferred name
- N-(2-hydroxyethyl)lactamide
- IUPAC
- 2-hydroxy-N-(2-hydroxyethyl)propanamide
- English name
- N-(2-Hydroxyethyl)lactamide
- Molecular formula
- C5H11NO3
- Molecular weight
- 133.15
Names & synonyms
N-(2-Hydroxyethyl)lactamide2-LactamidoethanolRefChem:4733581-hydroxyethane-1-(2'-hydroxyethyl)carbonamide5422-34-42-Hydroxy-N-(2-hydroxyethyl)propanamideLactamide MEAPropanamide, 2-hydroxy-N-(2-hydroxyethyl)-n-lactoyl ethanolamineLactic acid monoethanolamideLactamide, N-(2-hydroxyethyl)-N-2-Hydroxyethyllactamide
Show more names
MFCD0003Naetex-LAMlactamidemeaMackamide LMESchercomid LMEParapel LAM-100Upamide LACAMEA
MFCD00037805N-HydroxyaethyllactamidCCRIS 3086Lipamide LMEAIncromectant LMEAN-beta-HydroxyethyllactamideNSC 11062Monoethanolamine lactic acid amide
Database identifiers
- CAS
5422-34-4- PubChem CID
- 95457
- DTXSID
DTXSID20863533- ChEBI
CHEBI:173359- UNII
- 900T44YNC7
- EC Number
- 226-546-1
- Nikkaji
- J60.793B
Properties
Computed structural properties
- XLogP
- -1.4
- Topological polar surface area
- 69.6 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 3
- Heavy atoms
- 9
- Formal charge
- 0
- Complexity
- 94.2
Experimental & physicochemical properties
Cosmetics
Cosmetic ingredients (Lactamide MEA) -> CIR (Cosmetic Ingredient Review)
Skin conditioning; Humectant; Antistatic; Hair conditioning
FragrancesFragrance Ingredient (N-Lactoyl ethanolamine) -> IFRA transparency List
Food AdditivesFLAVORING AGENT OR ADJUVANT -> FDA Substance added to food
Density1.182-1.186
Solubility
Very soluble in water; insoluble in pentane and diethyl ether
Slightly soluble (in ethanol)
Boiling Point
380.00 °C. @ 760.00 mm Hg
372-380 °C
Refractive Index1.475-1.481
Physical Description
Liquid
Viscous, brownish liquid; Cooked brown roasted aroma
Physicochemical properties
- Boiling point
- 380.3 · 380.3±27.0 °C(Predicted)
- Density
- 1 · 1,2 g/cm3
- refractive index
- 1.482 to · 1.4820 to 1.4870
- FEMA
- 4256 · 4256 | N-LACTOYL ETHANOLAMINE
- FLAVIS Number
- 16.103 · 16.103 | Propanamide, 2-hydroxy-N-(2-hydroxyethyl)-.
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- 13.34 · 13.34±0.20(Predicted)
- color
- Light yellow to Yellow to Orange
- Odor
- cooked roasted
- JECFA Number
- 1774 · 1774
- Major Application
- flavors and fragrances
- Cosmetics Ingredients Functions
- HUMECTANTANTISTATICHAIR CONDITIONINGSKIN CONDITIONING
- Cosmetic Ingredient Review (CIR)
- N-(2-HYDROXYETHYL)LACTAMIDE (5422-34-4)
- InChI
- InChI=1S/C5H11NO3/c1-4(8)5(9)6-2-3-7/h4,7-8H,2-3H2,1H3,(H,6,9)
- InChIKey
- RZCHTMXTKQHYDT-UHFFFAOYSA-N
- SMILES
- C(NCCO)(=O)C(O)C
- LogP
- -2.31 · -2.31
- CAS DataBase Reference
- 5422 · 5422-34-4(CAS DataBase Reference)
- Substances Added to Food (formerly EAFUS)
- N-LACTOYL ETHANOLAMINE
- EWG's Food Scores
- 1 · 1-3
- FDA UNII
- 900 T44YNC7 · 900T44YNC7
- EPA Substance Registry System
- 2 · Propanamide, 2-hydroxy-N-(2-hydroxyethyl)- (5422-34-4)
- UNSPSC Code
- 12352116 · 12352116
- NACRES
- 21 · NA.21
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319
- Precautionary statements
- 264 · P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
- Risk Statements
- 36 · 36/37/38
- Safety Statements
- 26 · 26-36/37/39
- WGK Germany
- 3 · WGK 3
- RTECS
- 2400000 · OD2400000
- TSCA
- TSCA listed
- HS Code
- 2922.39 · 2922.39.5000
- Storage Class
- 10 · 10 - Combustible liquids
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 97.3% (1363 of 1401) of all reports.
Not Classified
Aggregated GHS information provided per 1401 reports by companies from 4 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory Information
Chemical: Propanamide, 2-hydroxy-N-(2-hydroxyethyl)-
Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)
Propanamide, 2-hydroxy-N-(2-hydroxyethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Propanamide, 2-hydroxy-N-(2-hydroxyethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 18-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21492
Propanamide, 2-hydroxy-N-(2-hydroxyethyl)-: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesNot Classified
Toxicology
Toxicity Summary
The CIR Expert Panel concluded that the ethanolamides listed subsequently are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating. The Expert Panel cautioned that these ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed...Lactamide MEA...
Safe for use in cosmetics, with qualifications
Safety data
- wgk
- WGK 3
- tsca
- TSCA listed
- rtecs
- OD2400000
- hs_code
- 2922.39.5000
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 26-36/37/39
- Storage Class
- 10 - Combustible liquids
- Hazard statements
- H315-H319
- REACH Registrations
- Active
- Precautionary statements
- P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Chemistry & industry
Pharmacology
Cellular LocationsCytoplasm
Uses & manufacturing
UsesCIR ingredient: Lactamide MEA
U.S. Production2023: 137,300 lb
Consumer UsesHumectant
Industry UsesProcessing aids not otherwise specified
Household ProductsInformation on 1 consumer products that contain Lactamide Mea in the following categories is provided:
Use Classification
Fragrance Ingredients
Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes
Flavoring Agents -> JECFA Flavorings Index
Cosmetics -> Skin conditioning; Humectant; Antistatic; Hair conditioning
General Manufacturing Information
Miscellaneous Manufacturing
Propanamide, 2-hydroxy-N-(2-hydroxyethyl)-: ACTIVE
Applications
Useslactamide MEA is a surfactant that can also act as a thickener, foam booster, and stabilizer.
Suppliers46 total
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
南京世洲生物科技有限公司025-85560043 15850508050 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
陕西缔都新材料有限公司029-63373950 17392216152 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
苏州维塔力生物医药有限公司512-68242903 13916956214 · [email protected]
北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
上海隆盛化工有限公司58099637 13585536065 · [email protected]
玛雅试剂+86 (573) 82222445 (0)18006601000 452520369 · [email protected]
TCI AMERICA800-4238616 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
九鼎化学（上海）科技有限公司4009209199 · [email protected]
HANGZHOU LEAP CHEM CO., LTD.+86-571-87711850 +86-15355479329 · [email protected]
上海源叶生物科技有限公司13636370518 · [email protected]
河北贞佳新材料有限公司0319-5925599 13315915972
BOC Sciences[email protected]
大连金点生物科技有限公司0411-0411-00000000 13644282108 · [email protected]
上海贤鼎生物科技有限公司021-021-52271985 17721149837 · [email protected]
北京珐默兹医药科技有限公司15811073878 · [email protected]
Shanghai Acmec Biochemical Technology Co., Ltd.+86-18621343501 · [email protected]
湖北诺纳科技有限公司59209883 17386169806 · [email protected]
杭州洁汉化工有限公司+86-571-86217390; +8618058761490 · [email protected]
上海臻励生物科技有限公司021-16621358918; 18516310516;16621358918;13045646768 · [email protected]
江苏艾康生物医药研发有限公司025-58851090 13913916777 · [email protected]
上海易恩化学技术有限公司400-400-1332688 18019345275 · [email protected]
厦门盈融达化工有限公司+86-0592-6210733 · [email protected]
北京迈瑞达科技有限公司010-82387566 · [email protected]
TCI Chemicals (India) Pvt. Ltd.[email protected]
河南威梯希化工科技有限公司0371-63284658 18135795563 · [email protected]
Aladdin Scientific[email protected]
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.+8618950047208 · [email protected]
上海迈瑞尔生化科技有限公司18621169109 · [email protected]
SHANGHAI KEAN TECHNOLOGY CO., LTD.+8613817748580 · [email protected]
常州英飒医药科技有限公司15151934985 · [email protected]
北京百灵威科技有限公司18210857532 18210857532 · [email protected]
陕西缔都医药化工有限公司+86-29-87569266 +86-17392581500 · [email protected]
Hefei TNJ Chemical Industry Co.,Ltd.+86-0551-65418671 +86-189 4982 3763 · [email protected]
上海易恩化学技术有限公司400-1332688 18019345275 · [email protected]
Additional notes
DefinitionChEBI: N-Lactoyl ethanolamine is a N-acylethanolamine.
Related reactions
2 records
Compound notes
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