Hydrochloric Acid → 8-(2-Chloro-4-fluorophenyl)-2-(1-(2-chloropyridin-4-yl)piperidin-4-ylamino)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-6-ol

HRID 100137

Reaction equation

HRID 100137 reaction equation
[Cl:1][c:2]1[c:3]([CH:9]2[c:10]3[n:11]([n:16][c:17]([NH:19][CH:20]4[CH2:21][CH2:22][N:23]([C:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32])[CH2:24][CH2:25]4)[n:18]3)[CH2:12][CH:13]([OH:15])[CH2:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[Cl:34][c:35]1[n:36][cH:37][cH:38][c:39]([F:41])[cH:40]1.[ClH:33]>>[Cl:1][c:2]1[c:3]([CH:9]2[c:10]3[n:11]([n:16][c:17]([NH:19][CH:20]4[CH2:21][CH2:22][N:23]([c:39]5[cH:38][cH:37][n:36][c:35]([Cl:34])[cH:40]5)[CH2:24][CH2:25]4)[n:18]3)[CH2:12][CH:13]([OH:15])[CH2:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 27827922-Chloro-4-fluoropyridineHCID 67345513tert-Butyl 4-(8-(2-chloro-4-fluorophenyl)-6-hydroxy-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)piperidine-1-carboxylate

Product 1

HCID 583979228-(2-Chloro-4-fluorophenyl)-2-(1-(2-chloropyridin-4-yl)piperidin-4-ylamino)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-6-ol

Sources & evidence

ORD record
ord-4be03fa3a4404d31bd54ca3bd5f82530
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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