Carbon tetrabromide → 5-(3-Bromopropyl)-4-methylpyrrolidin-2-one

Reaction equation

O[CH2:2][CH2:3][CH2:4][CH:5]1[NH:9][C:8](=[O:10])[CH2:7][CH:6]1[CH3:11].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:32]>>[Br:32][CH2:2][CH2:3][CH2:4][CH:5]1[NH:9][C:8](=[O:10])[CH2:7][CH:6]1[CH3:11]

Participants

Reactant 3

HCID 11205Carbon tetrabromide

HCID 11776Triphenylphosphine

HCID 184285635-(3-Hydroxypropyl)-4-methylpyrrolidin-2-one

Product 1

HCID 184285825-(3-Bromopropyl)-4-methylpyrrolidin-2-one

Procedure

A mixture of the title compound of EXAMPLE 235 is treated with triphenylphosphine and carbon tetrabromide by the method of EXAMPLE 224 to generate the title material.

Sources & evidence

ORD record: ord-ab222858b1814af8aece22c34acb14c9
Source dataset: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06046211

Reaction notes

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