Hydrochloric Acid → 3-[(Pyridin-3-ylmethyl)-amino]-phthalic acid

HRID 10043

Reaction equation

HRID 10043 reaction equation
C[O:2][C:3](=[O:22])[C:4]1[C:5](=[C:10]([NH:14][CH2:15][C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[CH:11]=[CH:12][CH:13]=1)[C:6]([O:8]C)=[O:7].COCCNC1C=CC=C(C(O)=O)C=1C(O)=O.Cl>>[N:18]1[CH:19]=[CH:20][CH:21]=[C:16]([CH2:15][NH:14][C:10]2[CH:11]=[CH:12][CH:13]=[C:4]([C:3]([OH:22])=[O:2])[C:5]=2[C:6]([OH:8])=[O:7])[CH:17]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 210401363-[(Pyridin-3-ylmethyl)-amino]-phthalic acid dimethyl esterHCID 219885193-(2-Methoxy-ethylamino)-phthalic acid

Product 1

HCID 219886213-[(Pyridin-3-ylmethyl)-amino]-phthalic acid

Procedure

3-[(Pyridin-3-ylmethyl)-amino]-phthalic acid dimethyl ester (0.91 g, 3.03 mmol) was treated in the same manner as described above for the synthesis of 3-(2-methoxy-ethylamino)-phthalic acid except the pH of crude reaction mixture was adjusted to 2–3 by dropwise addition of concentrated HCl. The solvent was then evaporated in vacuo leaving a dry salt mixture that was used without further purification.

Workup

  1. customreaction mixture
  2. customThe solvent was then evaporated in vacuo
  3. customleaving a dry salt mixture that
  4. customwas used without further purification

Sources & evidence

ORD record
ord-f7c3fa07821a4acd950e43369bfa1625
Source dataset
uspto-grants-2006_08
Patent number
US07091353B2

Linked notes

Loading…