4-Iodophenol → 4-(4Phenylbutoxy)iodobenzene

Reaction equation

[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15](Br)=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[I:19]C1C=CC(O)=CC=1>>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([I:19])=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 108944-Iodophenol

HCID 108704574-(4-Phenylbutoxy)bromobenzene

Product 1

HCID 187950194-(4Phenylbutoxy)iodobenzeneYield 80%

Procedure

Using the preparative procedure for 4-(4-phenylbutoxy)bromobenzene, except using 4-iodophenol in place of 4-bromophenol, gave 4-(4phenylbutoxy)iodobenzene in 80% yield.

Sources & evidence

ORD record: ord-dd26ae552fcc449e81ef622e8364d61e
Source dataset: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06048983

Reaction notes

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