Methanol → 2,6-Di-tert-butyl-4-(methoxymethyl)phenol

HRID 1004437

Reaction equation

HRID 1004437 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:6]([OH:13])=[C:5]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:4]=1.[CH3:18]O>Cl>[CH3:18][O:1][CH2:2][C:3]1[CH:4]=[C:5]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:6]([OH:13])=[C:7]([C:9]([CH3:10])([CH3:11])[CH3:12])[CH:8]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 6929Butylated hydroxymethylphenol

Product 1

HCID 69112,6-Di-tert-butyl-4-(methoxymethyl)phenolYield 94%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidCatalyst

Procedure

A solution of 4-hydroxymethyl-2,6-di-t-butylphenol (0.5 g) in methanol (10 mL) containing 1 drop of concentrated hydrochloric acid was stirred at ambient temperature for 1 hour. Evaporation of the solvent gave the title compound, 0.5 g, 94% yield as a white crystalline solid.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-113efb57cef44a829e4e591636f562cf
Source dataset
uspto-grants-2000_04
Patent number
US06048995

Linked notes

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