Iodine → HCID 21706514, compound

HRID 1005408

Reaction equation

HRID 1005408 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[C:3]=1[N+:9]([O-:11])=[O:10].II.[I:14]([O-])(=O)=O.[Na+].O>C(O)(=O)C.S(=O)(=O)(O)O>[I:14][C:7]1[C:2]([CH3:1])=[C:3]([N+:9]([O-:11])=[O:10])[C:4](=[O:8])[NH:5][CH:6]=1

Participants

7

Reactant 4

HCID 807IodineHCID 962WaterHCID 3453702-Hydroxy-4-methyl-3-nitropyridineHCID 23675764Sodium Iodate

Product 1

HCID 21706514HCID 21706514, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 1118Sulfuric AcidSolvent

Conditions

Temperature
75 °C

Procedure

To a solution of 4-methyl-3-nitro-2-pyridone (2.00 g, 13 mmol) in acetic acid (12 mL) and concentrated sulfuric acid (1.6 mL) was added iodine (1.32 g) and sodium iodate (0.55 g). The mixture was heated at 75° C. for 2.5 hours and then stirred at rt overnight. Water (100 mL) was added, and the precipitated 5-iodo-4-methyl-3-nitro-2-pyridone was collected by filtration (2.97 g, 82%).

Workup

  1. filtrationthe precipitated 5-iodo-4-methyl-3-nitro-2-pyridone was collected by filtration (2.97 g, 82%)

Sources & evidence

ORD record
ord-4e5a26406f1f46738924a78380e55939
Source dataset
uspto-grants-2000_04
Patent number
US06054470

Linked notes

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