Tetrahydrofuran → 5,6 diamino-2-(2,2-difluoro-ethoxy)-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide
Reaction equation
[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[NH2:1][c:2]1[n:3][c:4]([O:24][CH2:25][CH:26]([F:27])[F:28])[c:5]([C:6](=[O:7])[NH:8][CH:9]2[CH2:10][CH2:11][CH:12]([C:15]([F:16])([F:17])[F:18])[CH2:13][CH2:14]2)[cH:19][c:20]1[N+:21]([O-:22])=[O:23]>>[NH2:1][c:2]1[n:3][c:4]([O:24][CH2:25][CH:26]([F:27])[F:28])[c:5]([C:6](=[O:7])[NH:8][CH:9]2[CH2:10][CH2:11][CH:12]([C:15]([F:16])([F:17])[F:18])[CH2:13][CH2:14]2)[cH:19][c:20]1[NH2:21]Participants
3
Sources & evidence
- ORD record
- ord-e7fbc668af1643aab519eab31a0a06af
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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