Acetyl chloride → N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-2-dimethylaminocarbonyl-5-acetylaminobenzenesulfonamide
Reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][O:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[N:10]=[C:9]([NH:15][C:16]([NH:18][S:19]([C:22]2[CH:27]=[C:26]([NH2:28])[CH:25]=[CH:24][C:23]=2[C:29]([N:31]([CH3:33])[CH3:32])=[O:30])(=[O:21])=[O:20])=[O:17])[N:8]=1>CC(N(C)C)=O>[CH3:5][O:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[N:10]=[C:9]([NH:15][C:16]([NH:18][S:19]([C:22]2[CH:27]=[C:26]([NH:28][C:1](=[O:3])[CH3:2])[CH:25]=[CH:24][C:23]=2[C:29]([N:31]([CH3:33])[CH3:32])=[O:30])(=[O:21])=[O:20])=[O:17])[N:8]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
0.13 ml of acetyl chloride is slowly added dropwise to a mixture of 0.64 g of N-[(4,6dimethoxypyrimidin-2-yl)aminocarbonyl]-5-amino-2-dimethylaminocarbonylbenzenesulfonamide and 10 ml of dimethylacetamide. After the end of reaction, the reaction mixture is concentrated under reduced pressure and the residue is washed with water and ethyl acetate, to give 0.45 g of the desired product in high purity (>92%, HPLC).