Urea → 1,3(2H,4H)-isoquinolinedione

HRID 1006875Notes

Reaction equation

HRID 1006875 reaction equation
[C:1]1(=O)[O:7][C:5](=[O:6])[C:4]2=[CH:8][CH:9]=[CH:10][CH:11]=[C:3]2[CH2:2]1.[NH2:13]C(N)=O>O>[C:1]1(=[O:7])[NH:13][C:5](=[O:6])[C:4]2=[CH:8][CH:9]=[CH:10][CH:11]=[C:3]2[CH2:2]1

Participants

4

Reactant 2

HCID 1176UreaHCID 12801Homophthalic anhydride

Product 1

HCID 3494351,3(2H,4H)-isoquinolinedioneYield 52.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Homophthalic anhydride (20 g) and urea (60 g) were reacted at 170° C. for 1 hr. The reaction mixture was cooled, water (500 ml) was added thereto, and then the resulting precipitates were collected by filtration. The precipitate were washed with water and dried in hot air, to give 10.5 g of homophthalimide as a white powder.

Workup

  1. temperatureThe reaction mixture was cooled
  2. customthe resulting precipitates
  3. filtrationwere collected by filtration
  4. washThe precipitate were washed with water
  5. customdried in hot air

Sources & evidence

ORD record
ord-eed351f54faa42abad5759f85dee4ab7
Source dataset
uspto-grants-2004_09
Patent number
US06790844B2

Reaction notes

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