Hydrochloric Acid → (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-ethoxy-2-(2-fluoro-4-methoxy-phenyl)-acetamide

Reaction equation

[CH2:1]([CH3:2])[O:3][CH:4]([C:5](=[O:6])[OH:7])[c:8]1[c:9]([F:16])[cH:10][c:11]([O:14][CH3:15])[cH:12][cH:13]1.[ClH:17].[NH2:18][CH2:19][c:20]1[c:21]([OH:28])[cH:22][c:23]([C:24]#[N:25])[cH:26][cH:27]1>>[CH2:1]([CH3:2])[O:3][CH:4]([C:5](=[O:7])[NH:18][CH2:19][c:20]1[c:21]([OH:28])[cH:22][c:23]([C:24]#[N:25])[cH:26][cH:27]1)[c:8]1[c:9]([F:16])[cH:10][c:11]([O:14][CH3:15])[cH:12][cH:13]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 21904991(RS)-Ethoxy-(2-fluoro-4-methoxy-phenyl)-acetic acid

HCID 219056844-(Aminomethyl)-3-hydroxybenzonitrile

Product 1

HCID 21905309(RS)-N-(4-cyano-2-hydroxy-benzyl)-2-ethoxy-2-(2-fluoro-4-methoxy-phenyl)-acetamide

Sources & evidence

ORD record: ord-c90f8babbb334e7594855328501ea40a
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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