Hydrogen Peroxide → 1-Amino-1H-pyrrole-2-carboxamide
Reaction equation
[NH2:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]#[N:8].[OH-:9].[K+].OO>O>[NH2:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([NH2:8])=[O:9]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
1-Amino-1H-pyrrole-2-carbonitrile (2.52 g, 23.5 mmole) was suspended in 75 ml water, treated with potassium hydroxide (32 g, 0.57 mole), 30% hydrogen peroxide (2 ml) and stirred overnight at room temperature. The reaction mixture was cooled to 0° C. for 30 min and the product was isolated by filtration, washed with cold water and dried under vacuum to give 2.55 g of product (yield: 87%).
Workup
- temperatureThe reaction mixture was cooled to 0° C. for 30 min
- customthe product was isolated by filtration
- washwashed with cold water
- customdried under vacuum
Sources & evidence
- ORD record
- ord-48ba33c00e2948329ae0f23e9c965ce8
- Source dataset
- uspto-grants-2011_07
- Patent number
- US07977342B2
Reaction notes
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