Methanol → 2-([2-[(1-Methylethyl)oxy]ethyl}oxy)-8-(methoxy)-9-(tetrahydro-2H-Pyran-2-yl)-9H-purin-6-amine
Reaction equation
[Na].Br[C:3]1[N:4]([CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][O:21]2)[C:5]2[C:10]([N:11]=1)=[C:9]([NH2:12])[N:8]=[C:7]([O:13][CH2:14][CH2:15][O:16][CH:17]([CH3:19])[CH3:18])[N:6]=2.[CH3:26][OH:27]>>[CH3:18][CH:17]([O:16][CH2:15][CH2:14][O:13][C:7]1[N:6]=[C:5]2[C:10]([N:11]=[C:3]([O:27][CH3:26])[N:4]2[CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][O:21]2)=[C:9]([NH2:12])[N:8]=1)[CH3:19]Participants
4
Procedure
To methanol (120 ml) was added sodium (0.966 g). When the metal was dissolved, 8-bromo-2-({2-[(1-methylethyl)oxy]ethyl}oxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (5.69 g, 21.2 mmol) was added, heated to reflux and the solution stirred for 16 h, cooled to room temperature. The solvent was removed. Extracted with ethyl acetate after adding water, dried and concentrated to give the crude product which was purified through silica gel eluting with 2:1 ethyl acetate:petroleum ether to give the title compound (4.8 g).