Ethyl Acetoacetate → Rac-2-acetyl-4-methoxy-3-oxo-butyric acid ethyl ester

HRID 1011950

Reaction equation

[C:1]([O:7][CH2:8][CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[CH3:10][O:11][CH2:12][C:13](Cl)=[O:14]>>[CH2:8]([O:7][C:1](=[O:6])[CH:2]([C:3](=[O:4])[CH3:5])[C:13](=[O:14])[CH2:12][O:11][CH3:10])[CH3:9]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 96623Methoxyacetyl chloride

Product 1

HCID 87352689Rac-2-acetyl-4-methoxy-3-oxo-butyric acid ethyl ester

Procedure

In analogy to the procedure described in Intermediate 11A], ethyl acetoacetate and methoxyacetylchloride gave the crude title compound in quantitative yield as yellow oil. MS: 202.9 (MH+).

Sources & evidence

ORD record: ord-525af10a5d2c4ad5b29c769a55edaab5
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07977358B2

Linked notes

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