Dimethylacetamide → 2-Methyl-4-(2'-chloro-4'-fluorophenoxy)benzonitrile

Reaction equation

[C:21]([N:22]([CH3:23])[CH3:24])(=[O:25])[CH3:26].[Cl:12][c:13]1[c:14]([OH:20])[cH:15][cH:16][c:17]([F:19])[cH:18]1.[Cl:1][c:2]1[cH:3][c:4]([CH3:10])[c:5]([C:6]#[N:7])[cH:8][cH:9]1.[K:11]>>[c:2]1([O:20][c:14]2[c:13]([Cl:12])[cH:18][c:17]([F:19])[cH:16][cH:15]2)[cH:3][c:4]([CH3:10])[c:5]([C:6]#[N:7])[cH:8][cH:9]1

Participants

Reactant 4

HCID 31374Dimethylacetamide

HCID 748142-Chloro-4-fluorophenol

HCID 1427424-Chloro-2-methylbenzonitrile

HCID 5462222Potassium

Product 1

HCID 214295622-Methyl-4-(2'-chloro-4'-fluorophenoxy)benzonitrile

Sources & evidence

ORD record: ord-f9805597d46c4b1cb833440b160a3c11
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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