Methylamine → HCID 57925863, compound

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([P:9](=[O:14])([CH:12]=[CH2:13])[CH:10]=[CH2:11])=[CH:5][CH:4]=1.[CH3:15][NH2:16]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([P:9]2(=[O:14])[CH2:12][CH2:13][N:16]([CH3:15])[CH2:11][CH2:10]2)=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 6329Methylamine

HCID 57925986HCID 57925986, compound

Product 1

HCID 57925863HCID 57925863, compound

Procedure

(4-Methoxyphenyl)(divinyl) phosphine oxide (1.22 g, 5.88 mmol) and methylamine (0.53 mL, 6.18 mmol, 40% in water) was heated to 90° C. for 2 h. The reaction mixture was cooled to ambient temperature then extracted with DCM (3×). The combined organic extracts were dried (MgSO4) then concentrated in vacuo to afford the requisite product. MS: cal'd 240 (MH+), exp 240 (MH+)

Workup

extractionthen extracted with DCM (3×)
dry with materialThe combined organic extracts were dried (MgSO4)
concentrationthen concentrated in vacuo
customto afford the requisite product

Sources & evidence

ORD record: ord-34d50b43ae3a4b57ac468f2ac62ec89b
Source dataset: uspto-grants-2011_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07981874B2

Reaction notes

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