Hydrochloric Acid → 1-[2-(3-Methoxy-4-hydroxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:14][CH2:13]2)[CH:6]=[CH:7][C:8]=1[OH:9].[ClH:27]>C(O)C>[ClH:27].[ClH:27].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][N:15]([CH2:18][CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:16][CH2:17]2)[CH:6]=[CH:7][C:8]=1[OH:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 1-[2-(3-methoxy-4-hydroxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazine in ethanol is added 6 N hydrogen chloride aqueous solution until the pH is 3. The resulting solution is allowed to stand at ambient temperature overnight. The resultant crystals were filtered, washed with cold ethanol, and dried to give 61 mg of the title compound (57%).