Bromoacetic Acid → N-Isobutylglycine

Isobutylamine (50 mL, 0.5 mol) was cooled in an ice bath, and bromoacetic acid (6.1 g, 43.9 mmol) added slowly as a solid, insuring that each piece dissolved. After stirring overnight, the excess amine was removed and MeOH was added to the resulting oil. The resulting mixture was concentrated, and repeated using MeOH/HCl. Finally, a white solid was recrystallized from ethanol/ether to provide N-isobutylglycine.HCl (3.95 g, 53.7%).

1. dissolutiondissolved
2. customthe excess amine was removed
3. additionMeOH was added to the resulting oil
4. concentrationThe resulting mixture was concentrated
5. customFinally, a white solid was recrystallized from ethanol/ether

ORD record

ord-ebc41319e76649ef90442a2e3702c9e1

Source dataset

uspto-grants-2006_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07094758B2