Hydrogen Bromide → 2-Bromo-1-oxoindan-5-carbonitrile

HRID 1016552

Reaction equation

HRID 1016552 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]#[N:12])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.[Br:13]Br.Br>C(O)(=O)C.O>[Br:13][CH:3]1[CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[C:7]([C:11]#[N:12])[CH:6]=2)[C:2]1=[O:1]

Participants

6

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 3128961-oxo-2,3-dihydro-1H-indene-5-carbonitrile

Product 1

HCID 184072382-Bromo-1-oxoindan-5-carbonitrile

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

1-Oxoindane-5-carbonitrile is brominated with bromine in glacial acetic acid with addition of a catalytic amount of 48% strength HBr solution in water and affords 2-bromo-1-oxoindane-5-carbonitrile with a melting point of 115-118° C.

Sources & evidence

ORD record
ord-6e54ad14693d46c5a0dc92736c8e474b
Source dataset
uspto-grants-2002_11
Patent number
US06476059B1

Linked notes

Loading…