Pyridine → Acetamide, N-(3,5-dichlorophenyl)-
Reaction equation
N1C=CC=CC=1.[Cl:7][C:8]1[CH:9]=[C:10]([NH2:15])[CH:11]=[C:12]([Cl:14])[CH:13]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>C(Cl)(Cl)Cl>[Cl:7][C:8]1[CH:9]=[C:10]([NH:15][C:16](=[O:18])[CH3:17])[CH:11]=[C:12]([Cl:14])[CH:13]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
200 ml of pyridine are added dropwise to 100 g of 3,5-dichlorophenylamine in 3000 ml of chloroform, followed by addition of 90 ml of acetic anhydride. The reaction mixture is stirred for 12 hours at room temperature. The solvents are evaporated off under reduced pressure and the residue obtained is recrystallized from 1000 ml of ethyl acetate; m.p.=182° C.
Workup
- customThe solvents are evaporated off under reduced pressure
- customthe residue obtained
- customis recrystallized from 1000 ml of ethyl acetate
Sources & evidence
- ORD record
- ord-8aaa631de4e64c6eab26d209db2f0332
- Source dataset
- uspto-grants-2002_11
- Patent number
- US06482986B1
Reaction notes
Loading…