Ethylamine → 6-(Ethylamino)pyridine-3-carboxylic acid

Reaction equation

Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12]>>[CH2:11]([NH:13][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1)[CH3:12]

Participants

Reactant 2

HCID 6341Ethylamine

HCID 792226-Chloronicotinic acid

Product 1

HCID 117449946-(Ethylamino)pyridine-3-carboxylic acid

Procedure

This intermediate is prepared from 6-chloronicotinic acid and ethylamine by the same procedure as described for Example 35 step a). 1-Butanol was substituted for ethyl acetate for the extraction. Recrystallization (MeOH—CHCl3) yielded 0.53 g (50%).

Workup

extraction1-Butanol was substituted for ethyl acetate for the extraction
customRecrystallization (MeOH—CHCl3)
customyielded 0.53 g (50%)

Sources & evidence

ORD record: ord-263f43617b4f4ca7b9c9c14a546a1f8a
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06486183B1

Reaction notes

Loading…