Acetic Anhydride → N-(3,5-Dimethylphenyl)acetamide
Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([CH3:9])[CH:8]=1)[NH2:5].[C:10](OC(=O)C)(=[O:12])[CH3:11].C(N(CC)CC)C>C(Cl)Cl>[C:10]([NH:5][C:4]1[CH:6]=[C:7]([CH3:9])[CH:8]=[C:2]([CH3:1])[CH:3]=1)(=[O:12])[CH3:11]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 3,5dimethylaniline (20 g, 165 mmol), acetic anhydride (24 mL, 247 mmol) and triethylamine (70 mL, 495 mmol) in methylene chloride (300 mL is stirred at room temperature for 16 hours. The mixture is washed with water, dried (magnesium sulfate) and rotary evaporated. The residue is triturated with hexane and filtered to afford N-acetyl-3,5-dimethylaniline (25 g).
Workup
- washThe mixture is washed with water
- dry with materialdried (magnesium sulfate) and rotary evaporated
- customThe residue is triturated with hexane
- filtrationfiltered
Sources & evidence
- ORD record
- ord-9fbb8e492b9f4a319ac0cb4d89057ff5
- Source dataset
- uspto-grants-2002_11
- Patent number
- US06486190B1
Reaction notes
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