Lithium Hydroxide → (1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid lithium salt
Reaction equation
[OH-].[Li+:2].C([O:5][C:6](=[O:27])[CH2:7][C:8]1[N:9]([C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[CH:10]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[N:12]=1)C>O1CCOCC1>[Li+:2].[F:26][C:23]1[CH:22]=[CH:21][C:20]([N:9]2[CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[N:12]=[C:8]2[CH2:7][C:6]([O-:27])=[O:5])=[CH:25][CH:24]=1Participants
4
Procedure
1.1 mL 1M aqueous lithiumhydroxide solution was added to 300 mg (1,4-bis-(4-fluoro-phenyl)-1H-imidazol-2-yl)-acetic acid ethyl ester in 10 mL dioxane. The reaction was stirred 2 h at RT and evaporated to give 270 mg desired product. Rt: 1.09 min (method A), (M+H)+: 315