Hydrochloric Acid → 4-(3,3-Difluoropyrrolidin-1-yl)naphthalene-1-carbonitrile

HRID 102214

Reaction equation

HRID 102214 reaction equation
[C:22](=[O:23])([O-:24])[O-:25].[CH3:28][S:29]([CH3:30])=[O:31].[ClH:14].[F:15][C:16]1([F:21])[CH2:17][NH:18][CH2:19][CH2:20]1.[F:1][c:2]1[cH:3][cH:4][c:5]([C:12]#[N:13])[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12.[K+:26].[K+:27].[OH2:32]>>[c:2]1([N:18]2[CH2:17][C:16]([F:15])([F:21])[CH2:20][CH2:19]2)[cH:3][cH:4][c:5]([C:12]#[N:13])[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 27367341-Cyano-4-fluoronaphthaleneHCID 27828273,3-Difluoropyrrolidine

Product 1

HCID 230799684-(3,3-Difluoropyrrolidin-1-yl)naphthalene-1-carbonitrile

Sources & evidence

ORD record
ord-caf8a0d1311a48e895af5c33fef11fec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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