Tetrahydrofuran → methyl 5-amino-4-[7-[(2-methyl-1,3-dihydroisoindol-5-yl)methoxy]-3-oxo-1H-isoindol-2-yl]-5-oxopentanoate

HRID 102463

Reaction equation

HRID 102463 reaction equation
[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[CH3:36][N:37]1[CH2:38][c:39]2[cH:40][cH:41][c:42]([CH2:46][OH:47])[cH:43][c:44]2[CH2:45]1.[NH2:15][C:16]([CH:17]([CH2:18][CH2:19][C:20](=[O:21])[O:22][CH3:23])[N:24]1[C:25](=[O:34])[c:26]2[cH:27][cH:28][cH:29][c:30]([OH:33])[c:31]2[CH2:32]1)=[O:35].[O:1]=[C:2]([O:3][CH:4]([CH3:5])[CH3:6])[N:7]=[N:8][C:9]([O:10][CH:11]([CH3:12])[CH3:13])=[O:14]>>[NH2:15][C:16]([CH:17]([CH2:18][CH2:19][C:20](=[O:21])[O:22][CH3:23])[N:24]1[C:25](=[O:34])[c:26]2[cH:27][cH:28][cH:29][c:30]([O:33][CH2:46][c:42]3[cH:41][cH:40][c:39]4[c:44]([cH:43]3)[CH2:45][N:37]([CH3:36])[CH2:38]4)[c:31]2[CH2:32]1)=[O:35]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 45088797(2-methyl-2,3-dihydro-1H-isoindol-5-yl)methanolHCID 58389139Methyl 5-amino-4-(4-hydroxy-1-oxoisoindolin-2-yl)-5-oxopentanoate

Product 1

HCID 67335263methyl 5-amino-4-[7-[(2-methyl-1,3-dihydroisoindol-5-yl)methoxy]-3-oxo-1H-isoindol-2-yl]-5-oxopentanoate

Sources & evidence

ORD record
ord-6532060b84b34290ad67e0021af476be
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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