Trifluoroacetic acid → 3-(Azepan-1-yl)propan-1-amine
Reaction equation
[N:1]1([CH2:8][CH2:9][CH2:10][N:11]2C(=O)C3C(=CC=CC=3)C2=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.NN.C(O)(C(F)(F)F)=O>C(O)C>[N:1]1([CH2:8][CH2:9][CH2:10][NH2:11])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2-(3-(azepan-1-yl)propyl)isoindoline-1,3-dione (3.5 g) in Ethanol (20 mL) was added hydrazine (0.58 mL). The reaction mixture was reflux for 13 h and then cooled down to room temperature. TFA (2.0 mL) was added, the resulted white solid was filtered and the solvent was evaporated to give 3-(azepan-1-yl)propan-1-amine, used without further purification.
Workup
- temperatureThe reaction mixture was reflux for 13 h
- filtrationthe resulted white solid was filtered
- customthe solvent was evaporated
Sources & evidence
- ORD record
- ord-a96ef221609240c7a545a00ae414c4b8
- Source dataset
- uspto-grants-2014_05
- Patent number
- US08729081B2
Reaction notes
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