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Trifluoroacetic acid → 4-(2-(1-(Propylsulfonyl)piperidin-4-yl)-2,3-dihydrobenzofuran-5-yl)-1,2,3,6-tetrahydropyridine

HRID 1025507
Notes
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Reaction equation

HRID 1025507 reaction equation
[CH2:1]([S:4]([N:7]1[CH2:12][CH2:11][CH:10]([CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([C:22]4[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH:23]=4)[CH:20]=[CH:21][C:15]=3[O:14]2)[CH2:9][CH2:8]1)(=[O:6])=[O:5])[CH2:2][CH3:3].C(O)(C(F)(F)F)=O.FC1C2OC(C3(O)CCN(C4N=CC(CCC)=CN=4)CC3)CC=2C=C(C2CCNCC=2)C=1>>[CH2:1]([S:4]([N:7]1[CH2:12][CH2:11][CH:10]([CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([C:22]4[CH2:27][CH2:26][NH:25][CH2:24][CH:23]=4)[CH:20]=[CH:21][C:15]=3[O:14]2)[CH2:9][CH2:8]1)(=[O:6])=[O:5])[CH2:2][CH3:3]
ParticipantsProcedureSources & evidenceReaction notes

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 674657764-(7-Fluoro-5-(1,2,3,6-tetrahydropyridin-4-yl)-2,3-dihydrobenzofuran-2-yl)-1-(5-propylpyrimidin-2-yl)piperidin-4-olHCID 68211536tert-Butyl 4-(2-(1-(propylsulfonyl)piperidin-4-yl)-2,3-dihydrobenzofuran-5-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 674688454-(2-(1-(Propylsulfonyl)piperidin-4-yl)-2,3-dihydrobenzofuran-5-yl)-1,2,3,6-tetrahydropyridine

Procedure

Compound 10C was prepared from Compound 10B and TFA in a similar manner to the procedure described for Compound 1J in Example 1.

Sources & evidence

ORD record
ord-e1906a3d4c1a46cd917bbf9c6addf6b0
Source dataset
uspto-grants-2014_05
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08729084B2

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes