[O:1]1[CH2:5][CH2:4][O:3][C:2]1([CH2:9][CH2:10][OH:11])[CH2:6][CH2:7][OH:8].C(N(CC)CC)C.[S:19](Cl)([CH3:22])(=[O:21])=[O:20]>C(Cl)Cl>[CH3:22][S:19]([O:11][CH2:10][CH2:9][C:2]1([CH2:6][CH2:7][O:8][S:19]([CH3:22])(=[O:21])=[O:20])[O:3][CH2:4][CH2:5][O:1]1)(=[O:21])=[O:20]To a solution of 2,2′-(1,3-dioxolane-2,2-diyl)diethanol (1.3 g, 8.0 mmol) in methylene chloride (100 mL) was added triethylamine (3.4 mL, 24 mmol) at room temperature. The solution was cooled down to −40° C. and then mesyl chloride (1.65 mL, 20 mmol) was added dropwise. The reaction mixture was stirred at −40° C. for 30 min, then warmed up to 0° C. gradually. The reaction was quenched with saturated aqueous NaHCO3 solution. The aqueous layer was extracted with methylene chloride. The combined organic extracts were washed with brine, dried over Na2SO4, then evaporated to afford the crude product, 1,3-dioxolane-2,2-diyldiethane-2,1-diyl dimethanesulfonate: MS (m/e): 319 (M−1-1)+.
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