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Diisopropylethylamine → HCID 15616401, compound

HRID 1030479
Notes
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Reaction equation

HRID 1030479 reaction equation
Cl.Cl.[NH2:3][CH:4]1[CH:9]2[CH2:10][CH2:11][N:6]([CH2:7][CH2:8]2)[CH2:5]1.[CH3:12][O:13][C:14]1[CH:25]=[CH:24][C:17]([C:18]([NH:20][C:21](N)=[O:22])=[O:19])=[CH:16][CH:15]=1.C(N(C(C)C)CC)(C)C.C([O-])(=O)/C=C\C([O-])=O>N1C=CC=CC=1>[N:6]12[CH2:11][CH2:10][CH:9]([CH2:8][CH2:7]1)[CH:4]([NH:3][C:21]([NH:20][C:18](=[O:19])[C:17]1[CH:24]=[CH:25][C:14]([O:13][CH3:12])=[CH:15][CH:16]=1)=[O:22])[CH2:5]2
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 197853Quinuclidine, 3-amino-, dihydrochlorideHCID 5288227Maleate(2-)HCID 12757374N-Carbamoyl-4-methoxybenzamide

Product 1

HCID 15616401HCID 15616401, compound

Reagents, catalysts & solvents 1

HCID 1049
Pyridine
Solvent

Procedure

The above compound was prepared, following the procedure of Example 14b, from 3-aminoquinuclidine dihydrochloride (1.0 g, 5 mmol), 4-methoxybenzoylurea (0.97 g, 5 mmol) and di-isopropylethylamine (1.29 g, 10 mmol) in pyridine (20 ml). The product (1.12 g) was converted to 1:1 maleate half hydrate, mp 166°-168° C.

Workup

  1. customThe above compound was prepared

Sources & evidence

ORD record
ord-a00edf554abd483db126a4a172ef4873
Source dataset
uspto-grants-1992_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05106843

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes