Hydrogen Bromide → N-benzyl-5,6-dihydroxy-N-methylisoindolinium bromide
Reaction equation
[Cl-].[CH2:2]([N+:9]1([CH3:22])[CH2:17][C:16]2[C:11](=[CH:12][C:13]([O:20]C)=[C:14]([O:18]C)[CH:15]=2)[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[BrH:23]>>[Br-:23].[CH2:2]([N+:9]1([CH3:22])[CH2:10][C:11]2[C:16](=[CH:15][C:14]([OH:18])=[C:13]([OH:20])[CH:12]=2)[CH2:17]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1Participants
3
Procedure
To 1.0 g (3.13 mmol) of N-benzyl-5,6-dimethoxy-N-methylisoindolinium chloride, 10 ml of 48% hydrobromic acid was added, and the mixture was heated at reflux for 3 hours at an external temperature of from 110° to 130° C. The reaction solution was evaporated to dryness under reduced pressure, and the crystal residue was washed with 10 ml of acetone to obtain 1.05 g of the above identified compound.
Workup
- temperaturethe mixture was heated
- temperatureat reflux for 3 hours at an external temperature of from 110° to 130° C
- customThe reaction solution was evaporated to dryness under reduced pressure