Methyl iodide → HCID 178470072, compound
Reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH:11]=2)[C:6](=[O:19])[C:5]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:4]1[OH:25])C.C(N1C2C(=CC=C(C3C=NC=CC=3)C=2)C(=O)C(C(O)=O)=C1)C.[H-].[Na+].CI>>[OH:25][C:4]1[N:3]([CH3:1])[C:12]2[C:7]([C:6](=[O:19])[C:5]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:8][CH:9]=[C:10]([C:13]1[CH:14]=[CH:15][N:16]=[CH:17][CH:18]=1)[CH:11]=2Participants
5
Procedure
Ethyl 1,4-dihydro-2-hydroxy-1-methyl-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxylate was prepared from 7.20 g dioxobenzoxazine of Example 38, part (a), 1.66 g 60% sodium hydride and 1.95 ml methyl iodide according to the procedure of Example 38, part (b), and was obtained (4.50 g) as a yellow solid, m.p. about 184° C(decompn.).