Hydrochloric Acid → 5H,6H,7H-pyrrolo(3,4-b)pyridine dihydrochloride

Reaction equation

[NH:1]1[CH2:6][CH:5]=[CH:4][C:3]2[CH2:7][N:8](C(OCC)=O)[CH2:9][C:2]1=2.[ClH:15]>>[ClH:15].[ClH:15].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]2[CH2:7][NH:8][CH2:9][C:2]=12

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 18953638HCID 18953638, compound

Product 1

HCID 235036165H,6H,7H-pyrrolo(3,4-b)pyridine dihydrochloride

Procedure

8.5 g (44 mmol) of ethyl 5,7-dihydro-1H-pyrrolo-[3,4-b]pyridine-6-carboxylate are refluxed overnight in 90 ml of concentrated hydrochloric acid. The solution is concentrated, the residue is stirred with acetone, and the salt is filtered off with suction and dried in the air.

Workup

concentrationThe solution is concentrated
filtrationthe salt is filtered off with suction
customdried in the air

Sources & evidence

ORD record: ord-63017100ea8c47909c247d8996c1ec16
Source dataset: uspto-grants-1994_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05312823

Reaction notes

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