Oxalyl chloride → (Tetrahydro-2H-pyran-4-yl)acetyl chloride

HRID 1037842Notes

Reaction equation

[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=O)[CH2:3][CH2:2]1.C(Cl)(=O)C([Cl:14])=O>>[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([Cl:14])=[O:10])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 65578Oxalyl chloride

HCID 2773575Tetrahydropyran-4-ylacetic acid

Product 1

HCID 24229747(Tetrahydro-2H-pyran-4-yl)acetyl chloride

Procedure

Commercially available (tetrahydro-pyran-4-yl)-acetic acid and oxalyl chloride were processed as described for example 9A to afford the title compound. MS (DCI/NH3) m/z 159 (M+H)+.

Sources & evidence

ORD record: ord-519e0b281e4242f7bc2346e0218a968f
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08546583B2

Reaction notes

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