Ethyl 4-piperidinecarboxylate → Ethyl 1-(2,5-difluoro-4-methoxyphenyl)piperidine-4-carboxylate

HRID 104398

Reaction equation

HRID 104398 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([O:6][CH3:7])[c:8]([CH3:9])[cH:10]1.[Br:25][c:26]1[cH:27][c:28]([F:35])[c:29]([O:33][CH3:34])[cH:30][c:31]1[F:32].[CH3:11][CH2:12][c:13]1[cH:14][cH:15][cH:16][cH:17][c:18]1[N:19]1[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]1.[NH:36]1[CH2:37][CH2:38][CH:39]([C:40](=[O:41])[O:42][CH2:43][CH3:44])[CH2:45][CH2:46]1>>[c:26]1([N:36]2[CH2:37][CH2:38][CH:39]([C:40](=[O:41])[O:42][CH2:43][CH3:44])[CH2:45][CH2:46]2)[cH:27][c:28]([F:35])[c:29]([O:33][CH3:34])[cH:30][c:31]1[F:32]

Participants

5

Reactant 4

HCID 70770Ethyl 4-piperidinecarboxylateHCID 6083154-Bromo-1-methoxy-2-methylbenzeneHCID 27249834-Bromo-2,5-difluoroanisoleHCID 27364601-(2-Ethylphenyl)piperazine

Product 1

HCID 23111500Ethyl 1-(2,5-difluoro-4-methoxyphenyl)piperidine-4-carboxylate

Sources & evidence

ORD record
ord-f49b4e1d4bec432eb7850be79735c300
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

Loading…