Nitrogen → 1-(4-Chloromethyl-thiazol-2-yl)ethanone

HRID 1044778

Reaction equation

HRID 1044778 reaction equation
N#N.[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([CH:10]([OH:12])[CH3:11])[S:8][CH:9]=1>CC#N.O=[Mn]=O>[Cl:3][CH2:4][C:5]1[N:6]=[C:7]([C:10](=[O:12])[CH3:11])[S:8][CH:9]=1

Participants

5

Reactant 2

HCID 947NitrogenHCID 668198411-(4-Chloromethyl-thiazol-2-yl)-ethanol

Product 1

HCID 668199771-(4-Chloromethyl-thiazol-2-yl)ethanone

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6342AcetonitrileSolvent

Procedure

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-(4-chloromethyl-thiazol-2-yl)-ethanol (2.19 g, 12.31 mmol) in CH3CN (122 mL) was treated at rt with MnO2 (5.94 g, 61.52 mmol). The reaction mixture was stirred at rt until completion of the reaction, and then filtered through Celite. The solvent was removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 02: tR=0.84 min.

Workup

  1. filtrationfiltered through Celite
  2. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-79154917368b43f5baddd6744e4b48ad
Source dataset
uspto-grants-2013_10
Patent number
US08563714B2

Linked notes

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