Dichloromethane → 5-[2-(4,4-Difluoropiperidin-1-yl)ethoxy]benzofuran-2-carboxylic acid ethyl ester

HRID 104501

Reaction equation

HRID 104501 reaction equation
[CH2:20]([CH3:21])[O:22][C:23](=[O:24])[c:25]1[o:26][c:27]2[c:28]([cH:29]1)[cH:30][c:31]([OH:34])[cH:32][cH:33]2.[Cl:46][CH2:47][Cl:48].[F:35][C:36]1([F:45])[CH2:37][CH2:38][N:39]([CH2:42][CH2:43][OH:44])[CH2:40][CH2:41]1.[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[CH2:20]([CH3:21])[O:22][C:23](=[O:24])[c:25]1[o:26][c:27]2[c:28]([cH:29]1)[cH:30][c:31]([O:34][CH2:43][CH2:42][N:39]1[CH2:38][CH2:37][C:36]([F:35])([F:45])[CH2:41][CH2:40]1)[cH:32][cH:33]2

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 11776TriphenylphosphineHCID 179640292-(4,4-Difluoropiperidin-1-yl)ethan-1-olHCID 22228632Ethyl 5-hydroxybenzofuran-2-carboxylate

Product 1

HCID 670466975-[2-(4,4-Difluoropiperidin-1-yl)ethoxy]benzofuran-2-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-10996e16ba624645bf3bc7dc04541930
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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