3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl acetate → 3-(5-Methyl-1,2,4-oxadiazol-3-yl)phenol
Reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[N:15]=[C:14]([CH3:16])[O:13][N:12]=2)[CH:6]=1)(=O)C>Cl>[CH3:16][C:14]1[O:13][N:12]=[C:11]([C:7]2[CH:6]=[C:5]([OH:4])[CH:10]=[CH:9][CH:8]=2)[N:15]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 8.55 g (39.18 mmol) of the product obtained in Step C above in 120 ml of 1N HCl solution is heated at reflux for 90 minutes and is then left at ambient temperature overnight, with stirring. The precipitate is filtered off to yield the title product.
Workup
- temperatureat reflux for 90 minutes
- filtrationThe precipitate is filtered off
Sources & evidence
- ORD record
- ord-10a488ae5abf4fc5897e9468539c7837
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08569285B2
Reaction notes
Loading…