2-Bromo-2-methylpropionyl bromide → HCID 67411846, compound

HRID 1045391

Reaction equation

HRID 1045391 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7](=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[H][H].[Br:17][C:18]([CH3:23])([CH3:22])[C:19](Br)=[O:20]>>[C:7]([C:6]1[CH:5]=[CH:4][S:3][C:2]=1[NH:1][C:19](=[O:20])[C:18]([Br:17])([CH3:23])[CH3:22])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 3

HCID 886852-Bromo-2-methylpropionyl bromideHCID 644720(2-Aminothiophen-3-yl)(phenyl)methanoneHCID 178418361HCID 178418361, compound

Product 1

HCID 67411846HCID 67411846, compoundYield 86%

Procedure

1.0 g 2-Amino-3-benzoyl-thiophene (compound 3 wherein R3 is hydrogen) was acylated with 2-bromo-2-methylpropanoyl bromide to give 1.49 g (86%) of the title compound.

Sources & evidence

ORD record
ord-da0969570dee4fb5b405e6874ff4eff7
Source dataset
uspto-grants-2013_10
Patent number
US08569288B2

Linked notes

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