Hydrazine hydrate (1:1) → 1-(6-Bromo-3-methoxypyrazin-2-YL)hydrazine
Reaction equation
Br[C:2]1[C:3]([O:9][CH3:10])=[N:4][CH:5]=[C:6]([Br:8])[N:7]=1.O.[NH2:12][NH2:13]>C(O)C>[Br:8][C:6]1[N:7]=[C:2]([NH:12][NH2:13])[C:3]([O:9][CH3:10])=[N:4][CH:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
A 100 mL round bottom flask was charged with 3,5-dibromo-2-methoxypyrazine (0.50 g, 1.9 mmol), hydrazine hydrate (0.47 g, 9.4 mmol) and ethanol (5 mL). The resulting mixture was heated at 80° C. for 4 h. TLC indicated a complete conversion. Work-up: the reaction solution was concentrated in vacuo, to afford 0.5 g (crude) of the product as a brown solid, which was used in the next step without further purification.
Workup
- concentrationthe reaction solution was concentrated in vacuo
Sources & evidence
- ORD record
- ord-4e93e68367e340d0ab347829e2e30f5d
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08569300B2
Reaction notes
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