Trifluoroacetic acid → Trifluoroacetic acid
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)=[N:11][C:10]([CH3:26])=[N:9]2)=[CH:4][C:3]=1[CH3:27].[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>ClCCl>[C:30]([OH:32])([C:29]([F:34])([F:33])[F:28])=[O:31].[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[N:11][C:10]([CH3:26])=[N:9]2)=[CH:4][C:3]=1[CH3:27]Participants
5
Reactant 2
Product 2
Reagents, catalysts & solvents 1
Procedure
The product from step B (145.7 mg, 0.373 mmol) was dissolved in anhydrous dichloromethane (1 mL). Trifluoroacetic acid (100 uL, 1.298 mmol) was added dropwise with stirring. The reaction solution was stirred at room temperature for 16 h. The solution was concentrated and the crude residue was purified by RP-HPLC(C18; acetonitrile, water, 0.1% TFA) to afford the title compound. HPLC/MS: 291.0/293.0 (M+1), Rt=2.09 (LC4).